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Assistant Professor of Translational Molecular Medicine

Diego Marzese

Ph.D.

Department of Translational Molecular Medicine
John Wayne Cancer Institute

Diego Marzese joined the John Wayne Cancer Institute in 2011 as a Post-Doctoral Research fellow; during which, he studied genomic, transcriptomic, and epigenomic alterations involved in cutaneous melanoma and breast cancer. These studies resulted in the characterization of the first DNA methylation landscape of melanoma progression to brain metastasis. Today, Dr. Marzese’s research aims to unravel novel, clinically-relevant targets for melanoma and breast cancer patients through the utilization of functional genomics and epigenomics. His approach integrates RNA-Sequencing, Exome-Sequencing, DNA methylation, ChIP-Sequencing, and ATAC-Sequencing with CRIPSR-Cas9 technology to characterize transcriptional regulatory elements, including enhancers, silencers, and insulators, with cancer-state specific activation. This research impacts the way we understand drug-resistance and metastatic mechanisms in cancer patients by exploring the dynamic adaptation of tumor cells to micro-environmental perturbations.