{"id":3071,"date":"2025-11-13T06:16:20","date_gmt":"2025-11-13T06:16:20","guid":{"rendered":"https:\/\/www.saintjohnscancer.org\/blog\/?p=3071"},"modified":"2025-11-17T23:16:47","modified_gmt":"2025-11-17T23:16:47","slug":"intraoperative-radiation-therapy-a-personalized-approach-to-breast-cancer-treatment","status":"publish","type":"post","link":"https:\/\/www.saintjohnscancer.org\/blog\/breast\/intraoperative-radiation-therapy-a-personalized-approach-to-breast-cancer-treatment\/","title":{"rendered":"Intraoperative Radiation Therapy: A Personalized Approach to Breast Cancer Treatment"},"content":{"rendered":"\n<h2>Breast Surgical Oncologist and Radiation Oncologist at Providence, Saint John&rsquo;s Health Center Discuss Intraoperative Radiation Therapy for Breast Cancer Candidates<\/h2>\n<p>News often travels quickly&mdash;especially when major media outlets take on complex medical topics without consulting the experts who work with these treatments every day. At Saint John&rsquo;s Health Center, our radiation oncologists and surgical oncologists work together to provide clarity on one such innovation: Intraoperative Radiation Therapy (IORT) and its growing role in treating breast cancer. When recommending IORT to the right patient, it works exceptionally well. The key is thoughtful, individualized selection. <\/p>\n<blockquote><p><span style=\"font-size: 30px!important;line-height: 34px!important;letter-spacing: -1.5px;text-align: center\"> &ldquo;First select the correct patient for it and then after have a thorough discussion so that they know the risk and benefits of different approaches of radiation.&rdquo;<\/span><\/p><\/blockquote>\n\n<p style=\"text-align: right;padding-right: 5%;margin-bottom: 25px;margin-top: 0px\">&ndash; April Vassantachart, MD. <\/p>\n<h3>When Is Intraoperative Radiation Therapy Recommended?<\/h3>\n<p>IORT is not a one-size-fits-all treatment. Patients must meet specific criteria for it to be both safe and effective. When IORT is not suitable, External Beam Radiation Therapy (EBRT), and other alternative radiation options may be recommended. <\/p>\n<p>At Saint John&rsquo;s, each case is carefully reviewed by a multidisciplinary team&mdash;including radiation oncologists, surgical oncologists, medical oncologists and other specialists&mdash;who work together to determine the best approach and the appropriate radiation dosage for each patient. <\/p>\n<h3>What Is Intraoperative Radiation Therapy?<\/h3>\n<p>IORT is a specialized technique that delivers a single, concentrated dose of radiation directly to the area where the tumor was removed&mdash;during surgery, immediately after the tumor has been excised. This targeted approach treats the tissue most at risk while protecting surrounding healthy structures. <\/p>\n<h3>Who May Benefit from IORT?<\/h3>\n<p><strong>IORT is typically considered for<\/strong>: <\/p>\n<ul>\n<li>Early-stage, low-risk breast cancers (small tumors, clear surgical margins, and no lymph node involvement)<\/li>\n<li>Patients undergoing breast-conserving surgery (lumpectomy) who prefer a single-session radiation treatment rather than multiple sessions of EBRT<\/li>\n<\/ul>\n<p>Most of the patients getting IORT can do just 5 treatments of EBRT. Ultimately, the decision depends on the patient&rsquo;s unique diagnosis, preferences, and overall health. <\/p>\n<h3>Collaborative Expertise for Better Outcomes<\/h3>\n<p><figure id=\"attachment_3074\" aria-describedby=\"caption-attachment-3074\" style=\"width: 400px\" class=\"wp-caption alignright\"><img style=\"margin-top:-12px\" alt=\"A multi-disciplinary approach for IORT\" width=\"100%\" height=\"auto\" class=\"size-full wp-image-3074\" data-original=\"https:\/\/www.saintjohnscancer.org\/blog\/wp-content\/uploads\/sites\/11\/2025\/11\/A-multi-disciplinary-approach-for-IORT.jpg\"><figcaption id=\"caption-attachment-3074\" class=\"wp-caption-text\">A multi-disciplinary approach can maximimize outcomes of patients receiving IORT.<\/figcaption><\/figure>At Saint John&rsquo;s Health Center, our team of experts in radiation and surgical oncology work seamlessly together to decide when IORT is appropriate and who will benefit most. This close collaboration ensures that every patient receives personalized care designed for the best possible outcome. Below <a href=\"https:\/\/www.saintjohnscancer.org\/about-us\/people\/janie-grumley-m-d\/\">Janie Grumley, MD<\/a>, Director of the Margie Petersen Breast Center and Professor of Surgery, discusses with <a href=\"https:\/\/www.saintjohnscancer.org\/about-us\/people\/april-k-vassantachart-md\/\">April Vassantachart, MD<\/a>, radiation oncologist the benefits of IROT and patient outcomes. <\/p>\n<div style=\"float:none;width:100%;height:0px\">&nbsp;<\/div>\n<h3 style=\"font-size: 24px;line-height: 26px;font-weight: 500;text-align: center;padding-top: 50px;padding-bottom:20px\">Janie Grumley, MD and April Vassantachart, MD discuss how patients are selected for IORT<\/h3>\n<div style=\"margin-left:5%;margin-right:5%\"><iframe loading=\"lazy\" title=\"Pros and Cons of Breast IORT - A discussion with Janie Grumley, MD, and April Vassantachart, MD\" width=\"756\" height=\"425\" src=\"https:\/\/www.youtube.com\/embed\/TIVewJkgYAs?rel=0&amp;showinfo=0\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p style=\"text-align: center;font-size: 14px;line-height: 14px;margin-top: 15px;color: #101010;padding-bottom:25px\">Janie Grumley, MD, &amp; April Vassantachart, MD discuss pros and cons of Breast IORT.<\/p>\n<p>IORT is available at only a few centers in Los Angeles County&mdash;and Saint John&rsquo;s is proud to be one of them. Our multidisciplinary approach reflects our ongoing commitment to combining leading-edge technology with compassionate care, helping patients navigate breast cancer treatment with confidence and hope.<\/p>\n<p>To learn more about Intraoperative Radiation Therapy (IORT) please visit our webpage <a href=\"https:\/\/www.saintjohnscancer.org\/breast\/breast-cancer\/treatment\/intraoperative-radiation-therapy-iort-for-breast-cancer\/\">IROT for Breast Cancer.<\/a><\/p>\n\n","protected":false},"excerpt":{"rendered":"<p>Breast Surgical Oncologist and Radiation Oncologist at Providence, Saint John&rsquo;s Health Center Discuss Intraoperative Radiation Therapy for Breast Cancer Candidates&#8230;<\/p>\n","protected":false},"author":63,"featured_media":3073,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[149,225],"tags":[],"class_list":["post-3071","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-breast","category-innovations"],"acf":{"doc_author":"0","header_scripts":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Intraoperative Radiation 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