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At Providence Saint John\u2019s Health Center<\/span><\/span>, our Endocrine Tumor Program provides specialized, coordinated care for patients with adrenal and extra-adrenal neuroendocrine tumors. <\/p>\n
We are focused on delivering personalized care that improves outcomes and supports long-term health.<\/p>\n
What Are Pheochromocytoma & Paraganglioma?<\/h2>\n
Pheochromocytomas and paragangliomas are tumors that arise from chromaffin cells of the neuroendocrine system. These cells normally help regulate the body\u2019s response to stress by producing catecholamines such as adrenaline and noradrenaline. When tumors develop, excess hormone release can occur\u2014often in unpredictable episodes.<\/p>\n
Pheochromocytoma<\/h3>\n
Pheochromocytomas develop in the adrenal glands, which sit above each kidney and play a key role in hormone regulation. These tumors are more likely to produce hormones and frequently cause sudden spikes in blood pressure and other symptoms.<\/p>\n Paragangliomas form outside the adrenal glands, commonly along the spine or in the neck, chest, abdomen, or pelvis. Some paragangliomas produce hormones, while others do not. Because of their varied locations and behavior, diagnosis and treatment often require specialized imaging and multidisciplinary expertise.<\/p>\n<\/div>\n Symptoms vary depending on whether the tumor produces hormones and may occur in episodes triggered by stress, physical activity, or certain foods.<\/p>\n Common symptoms include:<\/strong><\/p>\n Additional symptoms may include:<\/strong><\/p>\n Some patients\u2014especially those with nonfunctional tumors\u2014may experience few or no symptoms. Even without symptoms, these tumors can grow and cause complications, underscoring the importance of early evaluation.<\/p>\n<\/div>\n Many pheochromocytomas and paragangliomas occur sporadically, with no known family history. However, up to 30\u201340% are linked to inherited genetic mutations.<\/p>\n Hereditary conditions associated with PPGLs include:<\/strong><\/p>\n Because of this strong genetic component, genetic counseling and testing are recommended for all patients diagnosed with PPGLs. Results help guide treatment decisions and long-term surveillance for patients and their families.<\/p>\n Accurate diagnosis requires a step-by-step approach combining hormone testing, advanced imaging, and genetic evaluation.<\/p>\n Initial testing determines whether excess hormones are present and may include:<\/p>\n These tests confirm whether the tumor is hormonally active.<\/p>\n Once hormone excess is identified, imaging is used to locate and characterize the tumor. Studies may include:<\/p>\n Given the high rate of hereditary involvement, genetic counseling is a critical part of care. Genetic findings influence treatment planning and determine appropriate long-term monitoring strategies.<\/p>\n<\/div>\n","layer_is_content_auto_columns":false,"sidebar_position":"right","widgets":false,"layer_icon":"","layer_icon_position":"left","layer_background_color":"bg-none","layer_id":""},{"acf_fc_layout":"layer_content_sidebar","layer_label":"","layer_headline":"","layer_intro":"","layer_content":" Treatment is tailored to each patient based on tumor location, hormone activity, genetic findings, and overall health. Care is coordinated across specialties to ensure safety and optimal outcomes.<\/p>\n Before treatment\u2014especially surgery\u2014patients often require medication to control blood pressure and heart rate, including:<\/p>\n This preparation reduces the risk of dangerous hormone surges and supports safer treatment.<\/p>\n Surgical removal is the definitive treatment for most pheochromocytomas and paragangliomas. When appropriate, minimally invasive adrenalectomy is performed. For tumors outside the adrenal glands, specialized surgical approaches are used based on tumor location. Our experienced surgical teams prioritize precision, safety, and recovery.<\/p>\n When tumors recur or spread, additional options may include:<\/p>\n With expert treatment and consistent follow-up, many patients achieve excellent long-term outcomes. Because PPGLs can recur\u2014even years after treatment\u2014lifelong monitoring is essential.<\/p>\n Follow-up care may include:<\/p>\n Our endocrine specialists coordinate long-term care plans to detect recurrence early and support both patients and their families over time.<\/p>\n Patients choose Saint John\u2019s for comprehensive, compassionate endocrine tumor care, including:<\/p>\n Here at Saint john’s, care extends beyond diagnosis\u2014our team partners with you through every stage of treatment and follow-up.<\/p>\n Most pheochromocytomas and paragangliomas are benign, but a small percentage can be malignant. Lifelong follow-up is recommended for all patients.<\/p>\n Yes. Even after successful treatment, these tumors can recur years later. This is why lifelong follow-up\u2014including periodic hormone testing, imaging, and blood pressure monitoring\u2014is an essential part of ongoing care.<\/p>\n In some cases, yes. Because many pheochromocytomas and paragangliomas are linked to inherited genetic mutations, genetic counseling and testing may be recommended. Identifying a hereditary condition can help guide screening and early detection for family members.<\/p>\n<\/div>\n","layer_is_content_auto_columns":false,"sidebar_position":"right","widgets":false,"layer_icon":"","layer_icon_position":"left","layer_background_color":"bg-gray-l","layer_id":""},{"acf_fc_layout":"layer_two_column","layer_label":"","layer_headline":"","layer_intro":"","layer_content_left":" If you have questions regarding Pheochromocytoma & Paraganglioma, or other endocrine conditions, please call today. Request an appointment<\/u><\/a><\/p>\n","layer_content_right":"![\"Paraganglioma](\"https:\/\/www.saintjohnscancer.org\/endocrine\/wp-content\/uploads\/sites\/3\/2026\/01\/Paraganglioma-Saint-Johns-Cancer-Institute.jpg\")
Paraganglioma<\/h3>\n
Signs and Symptoms<\/h2>\n
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Causes and Risk Factors<\/h2>\n
![\"Paraganlioma](\"https:\/\/www.saintjohnscancer.org\/endocrine\/wp-content\/uploads\/sites\/3\/2026\/01\/Paraganlioma-genetic-mutations.jpg\")
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Diagnosis of Pheochromocytoma & Paraganglioma<\/h2>\n
Biochemical Testing<\/h3>\n
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![\"Imaging](\"https:\/\/www.saintjohnscancer.org\/endocrine\/wp-content\/uploads\/sites\/3\/2026\/01\/Abdominal-Imaging-for-Adrenal-Tumors.jpg\")
Imaging Studies<\/h3>\n
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Genetic Testing<\/h3>\n
Treatment Options<\/h2>\n
Medical Preparation<\/h3>\n
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Surgery (Primary Treatment)<\/h3>\n
Treatment for Metastatic or Recurrent Disease<\/h3>\n
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Prognosis & Follow-Up<\/h2>\n
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Why Choose Saint John\u2019s for PPGL Care?<\/h2>\n
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Frequently Asked Questions<\/h2>\n
Are pheochromocytomas cancerous?<\/h3>\n
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Can pheochromocytoma or paraganglioma return after treatment?<\/h3>\n
Should my family members be tested if I am diagnosed with pheochromocytoma or paraganglioma?<\/h3>\n