{"id":21,"date":"2018-01-30T20:50:53","date_gmt":"2018-01-31T01:50:53","guid":{"rendered":"https:\/\/www.saintjohnscancer.org\/endocrine\/conditions\/cushings-syndrome-adrenal\/"},"modified":"2026-05-21T16:20:02","modified_gmt":"2026-05-21T20:20:02","slug":"cushings-syndrome-adrenal","status":"publish","type":"page","link":"https:\/\/www.saintjohnscancer.org\/endocrine\/conditions\/cushings-syndrome-adrenal\/","title":{"rendered":"Cushings Syndrome – Adrenal"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":null,"protected":false},"author":2,"featured_media":0,"parent":7,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"class_list":["post-21","page","type-page","status-publish","hentry"],"acf":{"layers":[{"acf_fc_layout":"layer_content_sidebar","layer_label":"","layer_headline":"","layer_intro":"","layer_content":"
\"Endocrine
The endocrine and thyroid team at Providence Saint John’s Health Center.<\/figcaption><\/figure>\n

Cushing\u2019s Syndrome is a hormonal disorder caused by prolonged exposure to elevated cortisol levels. Cortisol is a hormone produced by the adrenal glands that plays an important role in metabolism, blood pressure regulation, immune response, and the body\u2019s stress response.<\/p>\n

At Saint John\u2019s Health Center, our Endocrine Center of Excellence provides comprehensive evaluation and treatment for adrenal and endocrine disorders, including Cushing\u2019s Syndrome, adrenal tumors, thyroid diseases, and inherited endocrine conditions. Our multidisciplinary endocrine specialists work closely together to identify the underlying causes and develop individualized treatment plans.<\/p>\n

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What Is Cushing\u2019s Syndrome?<\/h2>\n
\"Cushing<\/a>
(Click to enlarge<\/strong>) Cushing’s Syndrome effects on the body<\/figcaption><\/figure>\n

Cushing\u2019s Syndrome occurs when the body is exposed to excessive cortisol levels over an extended period of time. Cortisol is a hormone produced by the adrenal glands that helps regulate metabolism, blood pressure, immune response, blood sugar, and the body\u2019s reaction to physical and emotional stress. Elevated cortisol may develop because the body is producing too much cortisol internally or because of long-term corticosteroid medication use.<\/p>\n

When cortisol levels remain abnormally elevated, multiple organ systems throughout the body can be affected. Patients may experience changes involving weight distribution, muscle strength, blood pressure, blood sugar, bone health, mood, sleep, and overall energy levels. Because symptoms often develop gradually and may overlap with more common medical conditions such as obesity, diabetes, fatigue, depression, or metabolic syndrome, diagnosis can sometimes be delayed or difficult to recognize in earlier stages.<\/p>\n

Signs and Symptoms of Cushing\u2019s Syndrome<\/h2>\n

The symptoms of Cushing\u2019s Syndrome can vary widely between patients depending on the severity and duration of cortisol excess. Some patients experience noticeable physical changes, while others may present with more subtle metabolic abnormalities or only mild symptoms. Some patients may experience only mild or \u201csubclinical\u201d Cushing\u2019s Syndrome with minimal outward symptoms despite abnormal laboratory findings. Even mild cortisol excess may contribute to long-term cardiovascular, metabolic, and bone-related complications if left untreated.<\/p>\n

\"What
There are several signs and symptoms of Cushing’s Syndrome that affect men and women.<\/figcaption><\/figure>\n

Common signs and symptoms may include:<\/strong><\/p>\n