Our research studies are focused on gliomas and melanoma brain metastasis (MBM). Current projects include examining different immunotherapy approaches (vaccines), Cancer Epigenetics, and the tumor microenvironment in gliomas and MBM. Other studies of melanoma brain metastasis mechanisms and tumor microenvironment using a xenograft brain metastasis models with I. Witz group at U. of Tel Aviv. Studies on ubiquitin E3 ligase as tumor suppressor gene in brain tumor progression A. Ciechanover, Technion-Israel Institute of Technology Haifa. Other studies are examining TME stem cell activation in stroke and brain tumor patients.