{"id":462,"date":"2018-11-07T20:12:24","date_gmt":"2018-11-07T20:12:24","guid":{"rendered":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/drug-discovery\/current-research-topics\/development-of-novel-chemo-and-radio-sensitizers-for-cancer-therapy\/"},"modified":"2022-09-21T21:05:59","modified_gmt":"2022-09-21T21:05:59","slug":"introduction-to-drug-repurposing-for-rare-diseases","status":"publish","type":"page","link":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/current-research-topics\/introduction-to-drug-repurposing-for-rare-diseases\/","title":{"rendered":"Introduction to Drug Repurposing for Rare Diseases"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":null,"protected":false},"author":2,"featured_media":0,"parent":458,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"class_list":["post-462","page","type-page","status-publish","hentry"],"acf":{"layers":[{"acf_fc_layout":"layer_content_image","layer_label":"","layer_headline":"Introduction to Drug Repurposing for Rare Diseases","layer_content":"<p>Although rare diseases affect a proportionally smaller number of patients, they represent a compelling unmet medical need as many of them lack effective treatments. The drug discovery and development process is long and expensive, and can take years to deliver new treatments to patients. A possible alternative to this process is to repurpose pre-existing, approved drugs for different diseases, bypassing conventional slow-moving drug discovery. Through the National Cancer Institute&#8217;s Department of Therapeutics Program, we have access to a diverse library of pre-approved compound sets.<\/p>\n","layer_link":"","layer_img":990,"layer_img_position":"right","layer_img_size":"contain","layer_img_is_fade":false,"layer_background_color":"","layer_id":""},{"acf_fc_layout":"layer_content_image","layer_label":"","layer_headline":"","layer_content":"<p>These compounds have accumulated preclinical and clinical data that can be utilized to make the process of further development much faster and more efficient. Our goal is to accelerate the development of new treatments for rare diseases by screening these compound library sets for new therapeutic applications. We apply new technologies and approaches for screening, such as phenotypic cell based disease models and high throughput screening (HTS).<\/p>\n<h3>Disease models:<\/h3>\n<p>Diffuse Intrinsic Pontine Glioma<\/p>\n","layer_link":"","layer_img":998,"layer_img_position":"right","layer_img_size":"contain","layer_img_is_fade":false,"layer_background_color":"","layer_id":""},{"acf_fc_layout":"layer_image_grid","image_grid":[{"image":{"ID":930,"id":930,"title":"Northwestern University","filename":"Northwestern-University.gif","filesize":27826,"url":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","link":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/current-research-topics\/introduction-to-drug-repurposing-for-rare-diseases\/northwestern-university\/","alt":"Northwestern University Logo","author":"12","description":"","caption":"","name":"northwestern-university","status":"inherit","uploaded_to":462,"date":"2019-05-14 20:38:43","modified":"2019-06-24 18:41:04","menu_order":0,"mime_type":"image\/gif","type":"image","subtype":"gif","icon":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-includes\/images\/media\/default.png","width":400,"height":210,"sizes":{"thumbnail":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University-150x150.gif","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University-300x158.gif","medium-width":300,"medium-height":158,"medium_large":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","medium_large-width":400,"medium_large-height":210,"large":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","large-width":400,"large-height":210,"1536x1536":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","1536x1536-width":400,"1536x1536-height":210,"2048x2048":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","2048x2048-width":400,"2048x2048-height":210,"blog-author-thumbnail":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","blog-author-thumbnail-width":150,"blog-author-thumbnail-height":79,"lowres":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University-100x53.gif","lowres-width":100,"lowres-height":53,"square-md":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","square-md-width":400,"square-md-height":210,"rectangle-md":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","rectangle-md-width":400,"rectangle-md-height":210,"16x9-xs":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","16x9-xs-width":400,"16x9-xs-height":210,"masthead":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","masthead-width":400,"masthead-height":210,"hero":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","hero-width":400,"hero-height":210,"hero-md":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","hero-md-width":400,"hero-md-height":210,"hero-sm":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","hero-sm-width":400,"hero-sm-height":210,"hero-xs":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","hero-xs-width":400,"hero-xs-height":210,"hero-xxs":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University-320x210.gif","hero-xxs-width":320,"hero-xxs-height":210,"gform-image-choice-sm":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","gform-image-choice-sm-width":300,"gform-image-choice-sm-height":158,"gform-image-choice-md":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","gform-image-choice-md-width":400,"gform-image-choice-md-height":210,"gform-image-choice-lg":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Northwestern-University.gif","gform-image-choice-lg-width":400,"gform-image-choice-lg-height":210}},"link":{"title":"Northwestern University ","url":"https:\/\/www.northwestern.edu\/","target":"_blank"}},{"image":{"ID":929,"id":929,"title":"Children\u2019s National Health Systems","filename":"Childrens-National-Health-System.png","filesize":7584,"url":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System.png","link":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/current-research-topics\/introduction-to-drug-repurposing-for-rare-diseases\/childrens-national-health-system\/","alt":"Children\u2019s National Health Systems Logo","author":"12","description":"","caption":"","name":"childrens-national-health-system","status":"inherit","uploaded_to":462,"date":"2019-05-14 20:37:53","modified":"2019-06-24 18:41:21","menu_order":0,"mime_type":"image\/png","type":"image","subtype":"png","icon":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-includes\/images\/media\/default.png","width":600,"height":400,"sizes":{"thumbnail":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System-300x200.png","medium-width":300,"medium-height":200,"medium_large":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System.png","medium_large-width":600,"medium_large-height":400,"large":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System.png","large-width":600,"large-height":400,"1536x1536":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System.png","1536x1536-width":600,"1536x1536-height":400,"2048x2048":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System.png","2048x2048-width":600,"2048x2048-height":400,"blog-author-thumbnail":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System.png","blog-author-thumbnail-width":150,"blog-author-thumbnail-height":100,"lowres":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System-100x67.png","lowres-width":100,"lowres-height":67,"square-md":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System-480x400.png","square-md-width":480,"square-md-height":400,"rectangle-md":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System-550x300.png","rectangle-md-width":550,"rectangle-md-height":300,"16x9-xs":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System-480x270.png","16x9-xs-width":480,"16x9-xs-height":270,"masthead":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System-600x400.png","masthead-width":600,"masthead-height":400,"hero":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System.png","hero-width":600,"hero-height":400,"hero-md":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System.png","hero-md-width":600,"hero-md-height":400,"hero-sm":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System-600x320.png","hero-sm-width":600,"hero-sm-height":320,"hero-xs":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System-460x260.png","hero-xs-width":460,"hero-xs-height":260,"hero-xxs":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System-320x260.png","hero-xxs-width":320,"hero-xxs-height":260,"gform-image-choice-sm":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System.png","gform-image-choice-sm-width":300,"gform-image-choice-sm-height":200,"gform-image-choice-md":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System.png","gform-image-choice-md-width":400,"gform-image-choice-md-height":267,"gform-image-choice-lg":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2019\/05\/Childrens-National-Health-System.png","gform-image-choice-lg-width":600,"gform-image-choice-lg-height":400}},"link":{"title":"Children\u2019s National Health Systems","url":"https:\/\/childrensnational.org\/","target":"_blank"}},{"image":false,"link":""}]}],"int_alt_page_title":"","int_page_description":"","int_masthead_image":false,"int_page_icon":"","int_secondary_cta_override":false,"int_secondary_cta_is_hidden":false,"header_scripts":""},"_links":{"self":[{"href":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-json\/wp\/v2\/pages\/462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-json\/wp\/v2\/comments?post=462"}],"version-history":[{"count":0,"href":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-json\/wp\/v2\/pages\/462\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-json\/wp\/v2\/pages\/458"}],"wp:attachment":[{"href":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-json\/wp\/v2\/media?parent=462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}