{"id":781,"date":"2019-03-29T23:44:45","date_gmt":"2019-03-29T23:44:45","guid":{"rendered":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/?page_id=781"},"modified":"2022-11-28T18:03:26","modified_gmt":"2022-11-28T18:03:26","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n<h2>Featured Publication<\/h2>\n<p><img class=\"alignleft wp-image-1169\" alt=\"\" width=\"252\" height=\"332\" data-original=\"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-content\/uploads\/sites\/9\/2020\/05\/assets-228x300.jpg\"><\/p>\n<p>Associate Professor Venkata Maidhar Yenugonda, M.Phil, Ph.D., and Research Associate Ariana Waters from the Drug Discovery and Nanomedicine Laboratory, along with Kesari S, and Allnutt AB, presents a review article in <a href=\"https:\/\/pubs.acs.org\/journal\/acncdm\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>ACS Chemical Neuroscience<\/strong><\/a> highlighting the importance of Cdk5 activity and function in the brain and demonstrates how deregulation of Cdk5 can contribute to the development of neurodegenerative conditions such as Alzheimer&rsquo;s and Parkinson&rsquo;s disease. To learn more read the full publication, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32286796\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><em>Physiological and pathological roles of Cdk5: potential directions for therapeutic targeting in neurodegenerative disease.<\/em><\/strong><\/a><\/p>\n<p><em>This article was also selected for ACS Editors&rsquo; Choice and the image was featured on the cover!<\/em><\/p>\n<p style=\"text-align: center;\"><a class=\"btn btn--primary\" href=\"https:\/\/pubs.acs.org\/doi\/suppl\/10.1021\/acschemneuro.0c00096\" target=\"_blank\" rel=\"noopener noreferrer\">Watch Publication Presentation<\/a><\/p>\n<h2>Publications<\/h2>\n<div id=\"em-accordions-0\" class=\"em-panels em-panels--accordions \"><nav class=\"em-panels__nav\"><div class=\"em-panels__controls\" role=\"tablist\"><div data-id=\"controls-accordions-0-panel-cancer\" class=\"em-panel__control\" role=\"tab\" aria-selected=\"false\" aria-expanded=\"false\" aria-controls=\"accordions-0-panel-cancer\">Cancer<\/div><div data-id=\"controls-accordions-0-panel-neuroscience\" class=\"em-panel__control\" role=\"tab\" aria-selected=\"false\" aria-expanded=\"false\" aria-controls=\"accordions-0-panel-neuroscience\">Neuroscience<\/div><div data-id=\"controls-accordions-0-panel-nanotechnolgy\" class=\"em-panel__control\" role=\"tab\" aria-selected=\"false\" aria-expanded=\"false\" aria-controls=\"accordions-0-panel-nanotechnolgy\">Nanotechnolgy<\/div><div data-id=\"controls-accordions-0-panel-pubmed-link\" class=\"em-panel__control\" role=\"tab\" aria-selected=\"false\" aria-expanded=\"false\" aria-controls=\"accordions-0-panel-pubmed-link\">PubMed Link<\/div><\/div><\/nav><div class=\"em-panel__container\">\n\t\t\t<div id=\"controls-accordions-0-panel-cancer\" class=\"em-panel__control\" role=\"tab\" aria-selected=\"false\" aria-expanded=\"false\" aria-controls=\"accordions-0-panel-cancer\">Cancer<\/div>\n\t\t\t<div id=\"accordions-0-panel-cancer\" class=\"em-panel\" role=\"tabpanel\" aria-hidden=\"true\" aria-labelledby=\"controls-accordions-0-panel-cancer\">\n\t\t\t\t<div class=\"em-panel__content\">\n<ul>\n<li>Yenugonda, V.M.; Nomura, N.; Kouznetsova,V.; Tsigelny, I.; Fogal, V.; Yang, J.; Nurmemmedov, E.; Kesari, S.;&nbsp; and Babic, I. A Novel Small Molecule Inhibitor of Mitochondrial p32. J Transl Med, 2017, 15, 210. PMID. 29047383<\/li>\n<li>Waye, S.; Naeem, A.; Choudhry, M.U.; Parasido, E.; Tricoli, L.; Sivakumar, A.; Mikhaiel, J.P.; Yenugonda, V.; Rodriguez, O.C.; Karam, S.D.; Rood, B.R.; Avantaggiati, M.L and Albanese.C. The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human human medulloblastoma cells, Aging (Albany NY). 2015, 7, 854-68, PMID: 26540407<\/li>\n<li>Ringer, L.; Sirajuddin,P.; Tricoli, L.; Waye,&nbsp; S.; Choudhry, M.;Parasido, E.; Sivakumar, A.; Heckler, M.; Naeem, A.; Abdelgawad, I.;&nbsp; Liu, X.; Feldman, A.;&nbsp;&nbsp; Lee, R.; Wu, Chin-Lee.;&nbsp; Yenugonda, V.M; Kallakury, B.; Dritschilo, A.; JohnLynch, J.; Schlegel, R.; Rodriguez, O.; Pestell, R.; Avantaggiati, M and Albanese., C. The Induction of the p53 Tumor Suppressor Protein Bridges the Apoptotic and Autophagic Signaling Pathways to Regulate Cell Death in Prostate Cancer Cells, Oncotarget. 2014, 5, 10678-91, PMID: 25296977.<\/li>\n<li>Yenugonda, V. M.; Deb, T. B.; Grindrod, S. C.; Dakshanamurthy, S.; Yang, Y.; Paige, M.; Brown, M. L. Fluorescent cyclin-dependent kinase inhibitors block the proliferation of human breast cancer cells. <em>Bioorg. Med. Chem.<\/em> 2011, <em>19<\/em>, 2714-2725. PMID: 21440449.<\/li>\n<\/ul>\n<p><\/p><\/div>\n\t\t\t<\/div>\n\t\t<\/div><div class=\"em-panel__container\">\n\t\t\t<div id=\"controls-accordions-0-panel-neuroscience\" class=\"em-panel__control\" role=\"tab\" aria-selected=\"false\" aria-expanded=\"false\" aria-controls=\"accordions-0-panel-neuroscience\">Neuroscience<\/div>\n\t\t\t<div id=\"accordions-0-panel-neuroscience\" class=\"em-panel\" role=\"tabpanel\" aria-hidden=\"true\" aria-labelledby=\"controls-accordions-0-panel-neuroscience\">\n\t\t\t\t<div class=\"em-panel__content\">\n<ul>\n<li>Levin, E. D.; Rezvani, A. H.; Wells, C.; Slade, S.; Yenugonda, V. M.; Liu, Y.; Brown, M. L.; Xiao, Y.; Kellar, K. J., alpha4beta2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats. Eur J Pharmacol 2018.<\/li>\n<li>Kong, H. S.; Song, Jun-ke.; Yenugonda, V.M.; Zhang, Li.; Shuo, T.; Kong, Y.; Du, Guan-hua.; Paige, M.; Brown, M.L. Preclinical studies of the potent and selective nicotinic &alpha;4&beta;2 receptor ligand VMY-2-95 Mol Pharm. 2015, 12, 393-402, PMID: 25533629.<\/li>\n<li>Yenugonda, V.M.; Xiao,Y.; Levin,E.D.; Rezvani, A.H.; Tran,T.; Al-Muhtasib, N.;&nbsp;&nbsp;&nbsp;&nbsp; Sahibzada, N.; Xie, T.; Wells, C.; Slade, S.; Johnson, J. E.; Dakshanamurthy, S.; Kong, H. S.; Tomita,Y.; Liu,Y.; Paige,M.; Kellar,K.J.; Brown,M.L. Design, Synthesis and Discovery of Picomolar Selective alpha4beta2 Nicotinic Acetylcholine Receptor Ligands. J. Med. Chem. 2013 56(21): 8404-21. PMID: 24047231.<\/li>\n<li>Liu, Y.; Richardson,&nbsp; J.;&nbsp; Tran, T.; Al-Muhtasib, N.;&nbsp; Xie, T.; Yenugonda,&nbsp; V. M.;&nbsp; Sexton,&nbsp; H. G.;&nbsp; Rezvani, A.H.; Levin, E. D.;&nbsp; Sahibzada, N.;&nbsp; Kellar, K. J.;&nbsp; Brown, M. L.;&nbsp; Xiao, Y.;&nbsp; Paige,&nbsp; M. Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective &alpha;4&beta;2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats. J. Med. Chem. 2013, 56, 3000-11. PMID: 23540678.<\/li>\n<\/ul>\n<p><\/p><\/div>\n\t\t\t<\/div>\n\t\t<\/div><div class=\"em-panel__container\">\n\t\t\t<div id=\"controls-accordions-0-panel-nanotechnolgy\" class=\"em-panel__control\" role=\"tab\" aria-selected=\"false\" aria-expanded=\"false\" aria-controls=\"accordions-0-panel-nanotechnolgy\">Nanotechnolgy<\/div>\n\t\t\t<div id=\"accordions-0-panel-nanotechnolgy\" class=\"em-panel\" role=\"tabpanel\" aria-hidden=\"true\" aria-labelledby=\"controls-accordions-0-panel-nanotechnolgy\">\n\t\t\t\t<div class=\"em-panel__content\">\n<ul>\n<li>Srinivas, R.; Karmali, P. P.; Pramanik, D.; Garu, A.; Yenugonda, V. M.; Majeti, B. K.; Ramakrishna, S.; Srinivas, G.; Chaudhuri, A. Cationic amphiphile with shikimic acid headgroup shows more systemic promise than its mannosyl analogue as DNA vaccine carrier in dendritic cell based genetic immunization. <em>J. Med. Chem.<\/em> 2010, <em>53<\/em>, 1387-1391. PMID: 20050668.<\/li>\n<li>Mukthavaram, R.; Marepally, S.; Yenugonda, V. M.; Vegi, G. N.; Sistla, R.; Chaudhuri, A. Cationic glycolipids with cyclic and open galactose head groups for the selective targeting of genes to mouse liver. <em>Biomaterials.<\/em> 2009, <em>30<\/em>, 2369-2384. PMID: 19157538.<\/li>\n<li>Hwang, S. H.; Rait, A.; Pirollo, K. F.; Zhou, Q.; Yenugonda, V. M.; Chinigo, G. M.; Brown, M. L.; Chang, E. H. Tumor-targeting nanodelivery enhances the anticancer activity of a novel quinazolinone analogue. <em>Mol. Cancer Ther.<\/em> 2008, <em>7<\/em>, 559-568. PMID: 18347143.<\/li>\n<li>Yenugonda, V. M.; Rajesh, M.; Madhavendra, S. S.; Chaudhuri, A. Distance of hydroxyl functionality from the quaternized center influence DNA binding and in vitro gene delivery efficacies of cationic lipids with hydroxyalkyl headgroups. <em>J. Med. Chem.<\/em> 2004, <em>47<\/em>, 5721-5728. PMID: 15509171.<\/li>\n<li>Yenugonda, V. M.; Rajesh, M.; Chaudhuri, A. Spacer-arm modulated gene delivery efficacy of novel cationic glycolipids: design, synthesis, and in vitro transfection biology. <em>J. Med. Chem.<\/em> 2004, <em>47<\/em>, 3938-3948. PMID: 15267233.<\/li>\n<\/ul>\n<p><\/p><\/div>\n\t\t\t<\/div>\n\t\t<\/div><div class=\"em-panel__container\">\n\t\t\t<div id=\"controls-accordions-0-panel-pubmed-link\" class=\"em-panel__control\" role=\"tab\" aria-selected=\"false\" aria-expanded=\"false\" aria-controls=\"accordions-0-panel-pubmed-link\">PubMed Link<\/div>\n\t\t\t<div id=\"accordions-0-panel-pubmed-link\" class=\"em-panel\" role=\"tabpanel\" aria-hidden=\"true\" aria-labelledby=\"controls-accordions-0-panel-pubmed-link\">\n\t\t\t\t<div class=\"em-panel__content\">\n<p><a class=\"btn btn--primary\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Venkata+Yenugonda\" target=\"_blank\" rel=\"noopener noreferrer\">View All Publications<\/a><\/p>\n<p><\/p><\/div>\n\t\t\t<\/div>\n\t\t<\/div><\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Featured Publication Associate Professor Venkata Maidhar Yenugonda, M.Phil, Ph.D., and Research Associate Ariana Waters from the Drug Discovery and Nanomedicine&#8230;<\/p>\n","protected":false},"author":12,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"class_list":["post-781","page","type-page","status-publish","hentry"],"acf":{"layers":false,"int_alt_page_title":"","int_page_description":"","int_masthead_image":false,"int_page_icon":"","int_secondary_cta_override":false,"int_secondary_cta_is_hidden":false,"header_scripts":""},"_links":{"self":[{"href":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-json\/wp\/v2\/pages\/781","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-json\/wp\/v2\/comments?post=781"}],"version-history":[{"count":0,"href":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-json\/wp\/v2\/pages\/781\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.saintjohnscancer.org\/translational-research-departments\/wp-json\/wp\/v2\/media?parent=781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}