Scott P. Layne, MD, FACP, FIDSA
Professor

Scott P. Layne, MD, FACP, FIDSA

Infectious Disease Medicine
COVID-19

SCOTT P. LAYNE, MD FACP FIDSA is a physician-scientist known for cross-disciplinary work in epidemiologic modeling, applied virology, large-scale laboratory technology and biological security policy. He is Professor Emeritus at the UCLA School of Public Health, former scientist at the Alfred Mann Foundation, and former Staff Member at the Los Alamos National Laboratory and Lawrence Livermore National Laboratory.

In a joint venture involving UCLA and LANL, Dr. Layne designed and built an automated high-throughput laboratory facility for analyzing numerous infectious disease samples. Its goal was to enable worldwide situational awareness on outbreaks and pandemics. In addition, he served as principal investigator of the NIAID/NIH Center of Excellence for Rapid Influenza Surveillance and Response, which conducted national and international studies of animal and human-derived influenza strains.

While at the Alfred Mann Foundation, Dr. Layne invented new and innovative medical technologies. He also developed a new diagnostic platform that enabled rapid point-of-care testing for various infectious diseases (such as influenza) and molecular medicine applications (such as liquid biopsies).

While at the Los Alamos National and Lawrence Livermore Laboratories, Dr. Layne worked on three different efforts. First, he examined living cells for nonlinear bioenergetic excitations in proteins (solitons) as predicted by computer simulations. His experimental work, however, found no clear evidence for such phenomenon and refuted previous experimental findings as artifacts. Second, he joined a select group of scientists who were tasked by the U.S. government to predict the future spread of HIV cases and AIDS-related deaths in Africa. His training as a physician was central for developing and validating mathematical models to analyze various interventions that may help to reduce the spread of HIV infections in large populations. Third, he undertook groundbreaking research that examined how HIV adheres to CD4 receptors and infects white blood cells. His work on the “physical chemistry” of HIV infection remains relevant for vaccine development to this day.

Dr. Layne has over 50 publications, including two books and six patents. Some of these publications have appeared in PNAS, Nature and Science. He is an editor of Firepower in the Lab (National Academy Press, 2001) and Jane’s Chem-Bio Handbook (2nd and 3rd editions).

In 1988, Dr. Layne organized the workshop A National Effort to Model AIDS Epidemiology for the White House Office of Science and Technology Policy. In 1999, he organized the meeting Automation in Thread Reduction and Infectious Diseases Research under the auspices of the Institute of Medicine and National Academy of Engineering. From 2008 to 2010, he served as a member of the National Biosurveillance Advisory Subcommittee as authorized by Homeland Security Presidential Directive 21.

He earned a Bachelor of Arts in chemistry from DePauw University in 1976, Doctor of Medicine from Case Western Reserve University in 1980, and trained in applied physics at Stanford University in 1986 to 1987. He earned board certifications in internal medicine and infectious diseases with a fellowship in adult infectious diseases. Currently, Dr. Layne practices adult infectious diseases on the west side of Los Angeles, California, and is a Fellow of the American College of Physicians and Infectious Diseases Society of America.

New coronavirus outbreak: Framing questions for pandemic prevention

Learn more about Dr. Layne at Pandefense Advisory