Participate In A Clinical Trial

For more information about any of our clinical trials, please call our main line for active trials.  Participants are chosen based on their medical history and candidacy, having met all the require criterial to participate in a clinical trial.  See Clinical Trials FAQs for additional information.

Please call, 310-582-7448

The clinical trials listed below represent active and enrolling trials here at Saint John’s Cancer Institute in Santa Monica and other facilities, such as trial locations in Burbank and Torrance, California.

Search using key terms or filter by Centers of Excellence or by Lead Doctor.

Title Center Name Physician

TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing Cancer

NCT ID : NCT04246671
Protocol Number : TAEK-VAC-HerBy-001
Phase : 1
Location : Saint John's Cancer Institute

All Solid Tumors

Santosh Kesari, M.D.

Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM (EF-32)

NCT ID : NCT04471844
Protocol Number : TRIDENT EF-32
Phase : N/A
Location : Saint John's Cancer Institute

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme

NCT ID : NCT04762069
Protocol Number : CNS-201
Phase : 2
Location : Saint John's Cancer Institute

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

REFLECTION: A Clinical Practice Learning Program for Galleri

NCT ID : NCT05205967
Protocol Number : GRAIL-MA-001
Phase : N/a
Location : Burbank, CA

Multiple Tumors

Ora Gordon, M.D.

Study Evaluating Efficacy & Safety of Afuresertib Plus Fulvestrant in Patients w/ Locally Advanced or Metastatic HR+/HER2- Breast Cancer

NCT ID : NCT04851613
Protocol Number : LAE205INT3101
Phase : Phase Ib/II
Location : Saint John's Cancer Institute

Breast Surgery and Oncology

Clinical Trials

Parvin Peddi, M.D.

Study to Evaluate the Safety and Efficacy of Magrolimab in Combination With Nab-Paclitaxel or Paclitaxel Versus Nab-Paclitaxel or Paclitaxel in Previously Untreated Adults With Metastatic Triple-Negative Breast Cancer

NCT ID : NCT04958785
Protocol Number : Gilead 586-6144
Phase : Phase II
Location : Saint John's Cancer Institute

Breast Surgery and Oncology

Clinical Trials

Parvin Peddi, M.D.

T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial

NCT ID : NCT04457596
Protocol Number : A011801
Phase : Phase III
Location : Saint John's Cancer Institute

Breast Surgery and Oncology

Clinical Trials

Parvin Peddi, M.D.

Testing Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases

NCT ID : NCT04647916
Protocol Number : SWOG S2007
Phase : Phase II
Location : Saint John's Cancer Institute

Breast Surgery and Oncology

Clinical Trials

Parvin Peddi, M.D.

Use of a Clinical Screening Tool to Address Cancer Health Disparities in the NCI Community Oncology Research Program (NCORP)

Protocol Number : DCP-001
Phase : N/A
Location : Santa Monica, CA

Multiple Tumors

Alison Conlin, M.D.

Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

NCT ID : 02194738
Protocol Number : A151216
Phase : N/A
Location : Santa Monica, CA

Minimally Invasive Chest Surgery and Thoracic Surgical Oncology

Alison Conlin, M.D.

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, ALCHEMIST Chemo-IO Study

NCT ID : 04267848
Protocol Number : A081801
Phase : 3
Location : Santa Monica, CA

Minimally Invasive Chest Surgery and Thoracic Surgical Oncology

Alison Conlin, M.D.

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

NCT ID : 02912559
Protocol Number : A021502
Phase : 3
Location : Santa Monica, CA

Gastrointestinal and Hepatobiliary Tumors

Alison Conlin, M.D.

Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy

NCT ID : 01901094
Protocol Number : A011202
Phase : 3
Location : Santa Monica, CA

Breast Surgery and Oncology

Alison Conlin, M.D.

A Phase 1/2 Study of PBI-200 in Subjects with NTRK-Fusion-Positive Advanced or Metastatic Solid Tumors

Protocol Number : PBI-200-101
Phase : 1/2
Location : Santa Monica, CA

Multiple Tumors

Santosh Kesari, M.D.

Assess Safety and Tolerability of Two Different Dose Levels of Subcutaneous Pegloticase in Subjects with Uncontrolled Gout Receiving Methotrexate

Protocol Number : HZNP-KRY-405
Phase : 1
Location : Santa Monica, CA

Multiple Tumors

Orrin M. Troum, M.D.

Neurosurgical evaluation of a mobile CT scanner Clinical Protocol

NCT ID : N/A
Protocol Number : xCAT IQ
Phase : N/A
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Chester Griffiths, M.D.

Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC (CONTACT-02)

NCT ID : 04446117
Protocol Number : XL184-315
Phase : 3
Location : Santa Monica, CA

Urology and Urologic Oncology

Przemyslaw Twardowski, M.D.

Study of Cabozantinib in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

NCT ID : 03170960
Protocol Number : XL184-021
Phase : Phase Ib
Location : Santa Monica, CA

All Solid Tumors

Multiple Tumors

Przemyslaw Twardowski, M.D.

White Button Mushroom Sup for the Reduction of PSA in Pts With Biochemically Rec or Therapy Naive Fav Risk Prostate CA

NCT ID : 04519879
Protocol Number : White Button Mushroom
Phase : 2
Location : Santa Monica, CA

Urology and Urologic Oncology

Przemyslaw Twardowski, M.D.

Evaluation of the PhageTech Virus BioResistor

NCT ID : 04756284
Protocol Number : VBRm BCA-01
Phase : Pilot/Feasibility
Location : Santa Monica, CA

Urology and Urologic Oncology

Jennifer Linehan, M.D.

Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies

NCT ID : 04566393
Protocol Number : ULI-EAP-100
Phase : Expanded Access
Location : Santa Monica, CA

Multiple Tumors

Naveed Wagle, M.D.

Caris Biorepository Research Protocol

NCT ID : 01499394
Protocol Number : TCBIO-001-0710
Phase : N/A
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

Synuclein-One Study

NCT ID : 04700722
Protocol Number : JWC_Synuclein
Phase : N/A
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Melita Petrossian, M.D.

Allogeneic Human Mesenchymal Stem Cells for Alzheimer’s Disease

NCT ID : 02833792
Protocol Number : STEM105-M-AD
Phase : 2
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

A Phase II Study in Patients With Moderate to Severe ARDS Due to COVID-19

NCT ID : 04780685
Protocol Number : STEM-107-COVID-19
Phase : 2
Location : Santa Monica, CA

COVID-19

Santosh Kesari, M.D.

Extension Study for Patients Who Had Not Met Criteria for Discontinuation in Previous Sponsored Belinostat Trials

NCT ID : 04184869
Protocol Number : SPI-BEL-502
Phase : N/A
Location : Santa Monica, CA

Multiple Tumors

Santosh Kesari, M.D.

An Open-label, Nonrandomized, Phase 1 Drug-Drug Interaction Study to Evaluate the Pharmacokinetics of Belinostat in Combination with Atazanavir in Patients with Advanced Relapsed/Refractory Solid Tumors or Hematological Malignancies

NCT ID : N/A
Protocol Number : SPI-BEL-107
Phase : 1
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

The PREVENTION Trial: Precision Recommendations to Optimize Neurocognition (PREVENTION)

NCT ID : 04082611
Protocol Number : Prevention
Phase : N/A
Location : Santa Monica, CA

Brain Tumors & Neuroscience

David Merrill, M.D.

Pilot Trial of Visual Healing® in Psilocybin-assisted Therapy for Alcohol Use Disorder

NCT ID : 04410913
Protocol Number : PTRIP002
Phase : 2
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Keith Heinzerling, M.D.

Intermediate-size Expanded Access to ONC201 for Patients with H3 K27M-mutant and/or Midline Gliomas

NCT ID : 04617002
Protocol Number : Oncoceutics_ONC028
Phase : Expanded Access
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Akanksha Sharma, MD

Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body (ON-TRK)

NCT ID : 04142437
Protocol Number : ON-TRK
Phase : N/A
Location : Santa Monica, CA

All Solid Tumors

Multiple Tumors

Santosh Kesari, M.D.

Open-label Study Investigating of OKN-007 Combined With Temozolomide in Patients With Recurrent Glioblastoma

NCT ID : 04388475
Protocol Number : OKN-007
Phase : 2
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

mSIM: Mobile Simultaneous Aerobic Exercise and Memory Training Intervention for Older Adults With Amnestic Mild Cognitive Impairment (mSIM)

NCT ID : 04185298
Protocol Number : MSIM
Phase : N/A
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Sarah McEwen

A Study of MPT-0118 in Subjects With Advanced or Metastatic Refractory Solid Tumors

NCT ID : 04859777
Protocol Number : MPT-0118-101
Phase : 1
Location : Santa Monica, CA

All Solid Tumors

Multiple Tumors

Przemyslaw Twardowski, M.D.

A Longitudinal Assessment of Tumor Evolution in Patients With Brain Cancer

NCT ID : 03425292
Protocol Number : JWCI-17-0801
Phase : N/A
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

The PREDICT Registry for DCIS Patients With DCISionRT Testing (PREDICT)

NCT ID : 03448926
Protocol Number : DCISionRT
Phase : N/A
Location : Santa Monica, CA

Breast Surgery and Oncology

Janie Grumley, M.D.

Evaluating the Clinical Efficacy of an Early-Stage Lung Cancer Detector

NCT ID : N/A
Protocol Number : CPC001-2017-S5P4-PSJHC
Phase : N/A
Location : Santa Monica, CA

Minimally Invasive Chest Surgery and Thoracic Surgical Oncology

Robert McKenna, M.D.

POA Retrospective Repository

NCT ID : 03326479
Protocol Number : COE-002-1116
Phase : N/A
Location : Santa Monica, CA

Multiple Tumors

Santosh Kesari, M.D.

DecisionDx-Melanoma Impact on Sentinel Lymph Node Biopsy Decisions and Clinical Outcomes (DECIDE)

NCT ID : N/A
Protocol Number : CBI_2019_SLNBprosp_001
Phase : N/A
Location : Santa Monica, CA

Melanoma, Skin and Soft Tissue Tumors

Richard Essner, M.D.

A Study to Assess Safety and Efficacy of Relatlimab With Ipilimumab in Participants With Advanced Melanoma Who Progressed on Anti-PD-1 Treatment

NCT ID : 03978611
Protocol Number : CA224-083
Phase : 1/2
Location : Santa Monica, CA

Melanoma, Skin and Soft Tissue Tumors

Timothy Kristedja, M.D.

Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer

NCT ID : 03860272
Protocol Number : C-800-01
Phase : 1
Location : Santa Monica, CA

Multiple Tumors

Przemyslaw Twardowski, M.D.

Trial With BNT111 and Cemiplimab in Combination or as Single Agents in Patients With Anti-PD1-refractory/Relapsed, Unresectable Stage III or IV Melanoma

NCT ID : 04526899
Protocol Number : BNT111-01
Phase : 2
Location : Santa Monica, CA

Melanoma, Skin and Soft Tissue Tumors

Przemyslaw Twardowski, M.D.

A Phase 3 Study of UGN-102 for Low Grade Intermediate Risk Non-Muscle-Invasive Bladder Cancer (ATLAS)

NCT ID : 04688931
Protocol Number : BL006
Phase : 3
Location : Santa Monica, CA

Urology and Urologic Oncology

Jennifer Linehan, M.D.

Liquid Biopsy Evaluation Of Biomarkers In Various Clinical Specimen Types From Patient With Cancer

NCT ID : N/A
Protocol Number : BIOC-035
Phase : Pilot/Feasibility
Location : Santa Monica, CA

Multiple Tumors

Santosh Kesari, M.D.

A First in Human Study of AdAPT-001 in Subjects With Refractory Solid Tumors (BETA-PRIME)

NCT ID : 04673942
Protocol Number : BETA PRIME
Phase : 1
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

Intratumoral Cavrotolimod Combined With Pembrolizumab or Cemiplimab in Patients With Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, or Other Advanced Solid Tumors

NCT ID : 03684785
Protocol Number : AST-008-102
Phase : 3
Location : Santa Monica, CA

All Solid Tumors

Multiple Tumors

Timothy Kristedja, M.D.

Axillary Reverse Mapping in Preventing Lymphedema in Patients With Breast Cancer Undergoing Axillary Lymph Node Dissection

NCT ID : 03927027
Protocol Number : A221702
Phase : 3
Location : Santa Monica, CA

Breast Surgery and Oncology

Janie Grumley, M.D.

Additional Support Program Via Text Messaging and Telephone-Based Counseling for Breast Cancer Patients Receiving Hormonal Therapy

NCT ID : 04379570
Protocol Number : A191901
Phase : 4
Location : Santa Monica, CA

Breast Surgery and Oncology

Janie Grumley, M.D.

A Study of Brentuximab Vedotin With Hodgkin Lymphoma (HL) and CD30-expressing Peripheral T-cell Lymphoma (PTCL)

NCT ID : NCT01716806
Protocol Number : SGN35-015
Phase : 2
Location : 181 S. Buena Vista St. Burbank, CA 91505

Hematology Oncology

Dr. Wong

Extended Treatment Protocol for Subjects Continuing to Benefit From Ibrutinib

NCT ID : 03229200
Protocol Number : PCYC-1145-LT
Phase : N/A
Location : 181 S. Buena Vista St. Burbank, CA 91505

Hematology Oncology

Dr. Wong

Discovery and Evaluation of Biomarkers for Diagnosis and Treatment of Disease

Protocol Number : MTG-015
Phase : N/A
Location : 181 S. Buena Vista St. Burbank, CA 91505

Multiple Tumors

Ora Gordon, M.D.

An Experiment to Evaluate the Safety of agenT-797 in COVID-19 Patients With Severe Difficulty Breathing

NCT ID : 04582201
Protocol Number : C-1300-01
Phase : 1
Location : Providence Saint John's Health Center, 2121 Santa Monica Blvd, Santa Monica, CA 90404

Clinical Trials

COVID-19

Terese Hammond, M.D.

Analysis of Immune and Organ System Responses in Patients with COVID-19

NCT ID : N/A
Protocol Number : ISB_LATINX
Phase : N/A
Location : Providence Saint John's Health Center, 2121 Santa Monica Blvd, Santa Monica, CA 90404

Clinical Trials

COVID-19

Dave Hoon, MSc, PhD & Jason Goldman, MD, MPH

Efficacy and Safety of Nerinetide in Participants With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy Excluding Thrombolysis (ESCAPE-NEXT)

NCT ID : 04462536
Protocol Number : NA-1-009
Phase : 3
Location : Providence Little Company of Mary Medical Center: 4101 Torrance Blvd, Torrance, CA

Clinical Trials

Stroke and Neurovascular Research

Translational Neurosciences

Jason Tarpley, M.D.

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

NCT ID : 02089217
Protocol Number : 13-004051
Phase : N/A
Location : Providence Little Company of Mary Medical Center: 4101 Torrance Blvd, Torrance, CA

Clinical Trials

Stroke and Neurovascular Research

Translational Neurosciences

Jason Tarpley, M.D.

Embolization of the Middle Meningeal Artery With ONYX™ Liquid Embolic System In the Treatment of Subacute and Chronic Subdural Hematoma (EMBOLISE)

NCT ID : 04402632
Protocol Number : MDT19027ONYX
Phase : N/A
Location : Providence Little Company of Mary Medical Center: 4101 Torrance Blvd, Torrance, CA

Clinical Trials

Stroke and Neurovascular Research

Translational Neurosciences

Jason Tarpley, M.D. & Walavan Sivakumar, M.D.

Preset for Occlusive Stroke Treatment

NCT ID : 03994822
Protocol Number : pCT-001-19
Phase : N/A
Location : Providence Little Company of Mary Medical Center: 4101 Torrance Blvd, Torrance, CA

Clinical Trials

Stroke and Neurovascular Research

Translational Neurosciences

Jason Tarpley, M.D.

The TESLA Trial: Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke

NCT ID : 03805308
Protocol Number : 2018-49
Phase : N/A
Location : Providence Little Company of Mary Medical Center: 4101 Torrance Blvd, Torrance, CA

Clinical Trials

Stroke and Neurovascular Research

Translational Neurosciences

Jason Tarpley, M.D.

EndoPredict® Extended Endocrine Trial (EXET)

NCT ID : 04016935
Protocol Number : ONC-010
Phase : N/A
Location : 181 S. Buena Vista St., Burbank, CA 91505

Breast Surgery and Oncology

Clinical Trials

Endocrine Tumors and Disorders

Erwin Grussie, M.D.

A Study of Adavosertib as Treatment for Uterine Serous Carcinoma (ADAGIO)

NCT ID : 04590248
Protocol Number : D601HC00002
Phase : 2b
Location : 181 S. Buena Vista St., Burbank, CA 91505

Clinical Trials

Gynecologic Oncology

Erwin Grussie, M.D.

Efficacy and Safety of Olaparib, Olaparib + Bevacizumab Compared to Bevacizumab + 5-Fluorouracil (FU)

NCT ID : 04456699
Protocol Number : MK-7339-003
Phase : 3
Location : 181 S. Buena Vista St., Burbank, CA 91505

Clinical Trials

Gastrointestinal and Hepatobiliary Tumors

Erwin Grussie, M.D.

A Study to Evaluate Enfortumab Vedotin in Subjects With Previously Treated Locally Advanced or Metastatic Malignant Solid Tumors (EV-202)

NCT ID : 04225117
Protocol Number : 7465-CL-202
Phase : 2
Location : 181 S. Buena Vista St., Burbank, CA 91505

All Solid Tumors

Cancer Support

Clinical Trials

Erwin Grussie, M.D.

Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexia

NCT ID : 04803305
Protocol Number : C3651010
Phase : 1
Location : 181 S. Buena Vista St., Burbank, CA 91505

Cancer Support

Clinical Trials

Raul Mena, M.D.

Study of AVB-S6-500 in Combination With Paclitaxel vs Paclitaxel in Patients With Platinum-Resistant Recurrent Ovarian Cancer

NCT ID : 04729608
Protocol Number : GOG-3059 AVB500-OC-004
Phase : 3
Location : 181 S. Buena Vista St., Burbank, CA 91505

Clinical Trials

Gynecologic Oncology

Erwin Grussie, M.D.

XB2001 in Combination With ONIVYDE + 5-FU/LV (+Folinic Acid) in Advanced Pancreatic Cancer (1-BETTER)

NCT ID : 04825288
Protocol Number : 2020-PT049
Phase : 1/2
Location : 181 S. Buena Vista St., Burbank, CA 91505

Clinical Trials

Gastrointestinal and Hepatobiliary Tumors

Dr. Wong

BESPOKE Study of ctDNA Guided Therapy in Colorectal Cancer

NCT ID : 04264702
Protocol Number : 20-041-NCP
Phase : N/A
Location : 181 S. Buena Vista St., Burbank, CA 91505

Clinical Trials

Gastrointestinal and Hepatobiliary Tumors

Erwin Grussie, M.D.

Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM (EF-32)

NCT ID : 04471844
Protocol Number : Trident EF-32
Phase : N/A
Location : 181 S. Buena Vista St., Burbank, CA 91505

Brain Tumors & Neuroscience

Clinical Trials

Naveed Wagle, M.D.

Efficacy and Safety Comparison of Niraparib to Placebo in Participants With Either Human Epidermal Growth Factor 2 Negative (HER2-) Breast Cancer Susceptibility Gene Mutation (BRCAmut) or Triple-Negative Breast Cancer (TNBC) With Molecular Disease (ZEST)

NCT ID : 04915755
Protocol Number : 213831
Phase : 3
Location : 181 S. Buena Vista St., Burbank, CA 91505

Breast Surgery and Oncology

Clinical Trials

Erwin Grussie, M.D.

A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy (Astefania)

NCT ID : 04873362
Protocol Number : WO42633
Phase : 3
Location : 181 S. Buena Vista St., Burbank, CA 91505

Breast Surgery and Oncology

Clinical Trials

Erwin Grussie, M.D.

A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)

NCT ID : 04586231
Protocol Number : Merck -6482-011
Phase : 3
Location : Santa Monica

Urology and Urologic Oncology

Przemyslaw Twardowski, M.D.

Study to Compare Adjuvant Immunotherapy of Bempegaldesleukin Combined With Nivolumab Versus Nivolumab After Complete Resection of Melanoma in Patients at High Risk for Recurrence (PIVOT-12)

NCT ID : 04410445
Protocol Number : 20-214-29/CA045-022
Phase : 3
Location : Santa Monica, CA

Melanoma, Skin and Soft Tissue Tumors

Steven O' Day, M.D.

Substudy 02C: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Stage III Melanoma Who Are Candidates for Neoadjuvant Therapy (MK-3475-02C)

NCT ID : 04303169
Protocol Number : MK-3475-02C
Phase : 3
Location : Santa Monica, CA

Melanoma, Skin and Soft Tissue Tumors

Timothy Kristedja, M.D.

Substudy 02B: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With First Line (1L) Advanced Melanoma (MK-3475-02B)

NCT ID : 04305054
Protocol Number : MK-3475-02B
Phase : 3
Location : Santa Monica, CA

Melanoma, Skin and Soft Tissue Tumors

Przemyslaw Twardowski, M.D.

Autologous Dendritic Cells Loaded With Autologous Tumor Associated Antigens for Treatment of Advanced Epithelial Ovarian Carcinomas

NCT ID : 02033616
Protocol Number : CL-OVA-P01-00-US
Phase : 2
Location : Burbank, CA

Gynecologic Oncology

Raul Mena, M.D.

Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)

NCT ID : 03425643
Protocol Number : MK-7339-008
Phase : 3
Location : Santa Monica, CA

Minimally Invasive Chest Surgery and Thoracic Surgical Oncology

Timothy Kristedja, M.D.

A Study to Evaluate the Efficacy and Safety of Remdesivir Plus Tocilizumab Compared With Remdesivir Plus Placebo in Hospitalized Participants With Severe COVID-19 Pneumonia (REMDACTA)

NCT ID : 04409262
Protocol Number : WA42511
Phase : 3
Location : Santa Monica, CA

COVID-19

Terese Hammond, M.D.

UV1 Vaccination Plus Nivolumab and Ipilimumab in Treatment of Melanoma

NCT ID : 04382664
Protocol Number : UV1-202
Phase : 2
Location : Santa Monica, CA

Melanoma, Skin and Soft Tissue Tumors

Przemyslaw Twardowski, M.D.

Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients

NCT ID : 04291105
Protocol Number : VYR-VSV2-203
Phase : 2
Location : Santa Monica, CA

All Solid Tumors

Steven O' Day, M.D.

Phase 1 Study of SL-172154 (SIRPα-Fc-CD40L) in Subjects With Ovarian Cancer

NCT ID : 04406623
Protocol Number : SL03-OHD-101
Phase : 1
Location : Santa Monica, CA

Gynecologic Oncology

Timothy Kristedja, M.D.

Enfortumab Vedotin and Pembrolizumab, With or Without Chemotherapy, vs. Chemotherapy Alone in Untreated Locally Advanced or Metastatic Urothelial Cancer (EV-302)

NCT ID : 04223856
Protocol Number : SGN22E-003
Phase : 3
Location : Santa Monica, CA

Urology and Urologic Oncology

Przemyslaw Twardowski, M.D.

Expanded Access to ONC201 for Patients With H3 K27M-mutant and/or Midline High Grade Gliomas

NCT ID : 03134131
Protocol Number : ONC018
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

⁸⁹Zr-Df-IAB22M2C (CD8 PET Tracer) for PET/CT in Patients With Metastatic Solid Tumors

NCT ID : 03802123
Protocol Number : IAB-CD8-201
Phase : 2
Location : Santa Monica, CA

All Solid Tumors

Przemyslaw Twardowski, M.D.

Imaging Study to Investigate the Safety and Diagnostic Performance of rhPSMA 7.3 (18F) in Newly Diagnosed Prostate Cancer

NCT ID : 04186819
Protocol Number : BED-PSMA-301
Phase : 3
Location : Santa Monica, CA

Urology and Urologic Oncology

Dr. Twardowski and Dr. Hanelin

DOM-INNATE: Study of SGX942 for the Treatment of Oral Mucositis in Patients With Concomitant Chemoradiation Therapy for Head and Neck Cancer

NCT ID : 03237325
Protocol Number : IDR-OM-02
Phase : 3
Location : Burbank, CA

Brain Tumors & Neuroscience

Raul Mena, M.D.

A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome (GRACE)

NCT ID : 03697109
Protocol Number : CORT125134-455
Phase : 3
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Garni Barkhoudarian, M.D.

A Phase 3 Study of Pembrolizumab in Combination with Carboplatin/Taxane (Paclitaxel or Nab-paclitaxel) Followed by Pembrolizumab with or without Maintenance Olaparib in the First-line Treatment of Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) (KEYLYNK-008)

NCT ID : 03976362
Protocol Number : MK-7339-008
Phase : 3
Location : Burbank, CA

Minimally Invasive Chest Surgery and Thoracic Surgical Oncology

Raul Mena, M.D.

A Phase 3 Study of Pembrolizumab in Combination with Pemetrexed/Platinum (Carboplatin or Cisplatin) Followed by Pembrolizumab and Maintenance Olaparib vs Maintenance Pemetrexed in the First-Line Treatment of Participants with Metastatic Nonsquamous Non-Small-Cell Lung Cancer (KEYLYNK-006)

NCT ID : 03976323
Protocol Number : MK-7339-006
Phase : 3
Location : Burbank, CA

Minimally Invasive Chest Surgery and Thoracic Surgical Oncology

Raul Mena, M.D.

A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton’s Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination With Rituximab Versus Placebo in Combination With Rituximab in Treatment Naïve Subjects With Follicular Lymphoma (PERSPECTIVE)

NCT ID : 02947347
Protocol Number : PCYC-1141-CA
Phase : 3
Location : Burbank, CA

Hematology Oncology

Raul Mena, M.D.

A Phase III Prospective Randomized Trial of Acupuncture for Treatment of Radiation-Induced Xerostomia in Patients With Head and Neck Cancer

NCT ID : 02589938
Protocol Number : IRB00031366
Phase : 3
Location : Burbank, CA

Brain Tumors & Neuroscience

Raul Mena, M.D.

Pemetrexed for the Treatment of Chordoma

NCT ID : 03955042
Protocol Number : JWCI-18-0704
Phase : 1
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

A Phase 1/2a Study to Evaluate the Safety, Tolerability, and Efficacy of Relatlimab Administered in Combination with Ipilimumab or Ipilimumab Alone in Participants with Unresectable or Metastatic Melanoma Who Have Progressed on Anti-PD-1 Therapy

NCT ID : 03978611
Protocol Number : CA224-083
Phase : 1/2a
Location : Santa Monica, CA

Melanoma, Skin and Soft Tissue Tumors

Steven O' Day, M.D.

Perioperative Pembrolizumab (MK-3475) Plus Cystectomy Versus Cystectomy Alone in Cisplatin-ineligible Participants With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905)

NCT ID : 03924895
Protocol Number : MK-3475-905/KEYNOTE-905/EV-303
Phase : 3
Location : Santa Monica, CA

Urology and Urologic Oncology

Przemyslaw Twardowski, M.D.

Perioperative Pembrolizumab (MK-3475) Plus Neoadjuvant Chemotherapy Versus Perioperative Placebo Plus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle-invasive Bladder Cancer (MIBC) (MK-3475-866/KEYNOTE-866)

NCT ID : 03924856
Protocol Number : MK-3475-866/KEYNOTE-866
Phase : 3
Location : Santa Monica, CA

Urology and Urologic Oncology

Przemyslaw Twardowski, M.D.

Memantine XR and Pregabalin for Chemotherapy-Induced Peripheral Neuropathy

NCT ID : 03709888
Protocol Number : JWCI-17-0101
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

An Exploratory Study of Caregiver Burden Among Family Caregivers of Patients With Cancer

NCT ID : 03069105
Protocol Number : JWCI-16-1201
Location : Santa Monica, CA

Cancer Support

Dr. Saria

CancerLife: Patient-Driven Solution in Cancer Care

NCT ID : 03371147
Protocol Number : JWCI-17-1001
Location : Santa Monica, CA

Cancer Support

Dr. Saria

Overactive Bladder Treatment Using StimRouter Neuromodulation System: A Prospective Randomized Trial

NCT ID : 02873312
Protocol Number : CP-STMR-OAB-002
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Jean-Phillip Langevin, M.D.

Optune Delivered Electric Field Therapy and Bevacizumab in Treating Patients With Recurrent or Progressive Grade 2 or 3 Meningioma

NCT ID : 02847559
Protocol Number : NU 16C02
Phase : 2
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

A Phase I Study of AGEN1181, an Fe-Engineered Anti-CTLA-4 Monoclonal Antibody as Monotherapy and in Combination with AGEN2034, an Anti-PD-1 Monoclonal Antibody, in Subjects with Advanced Cancer

NCT ID : 03860272
Protocol Number : C-800-01
Phase : 1
Location : Santa Monica, CA

All Solid Tumors

Steven O' Day, M.D.

A Randomized, Open-Label, Phase 2 Study of Nivolumab in Combination With Ipilimumab or Nivolumab Monotherapy in Participants With Advanced or Metastatic Solid Tumors of High Tumor Mutational Burden (TMB-H)

NCT ID : NCT03668119
Protocol Number : CA209-848
Phase : 2
Location : Santa Monica, CA

Breast Surgery and Oncology

Melanoma, Skin and Soft Tissue Tumors

Steven O' Day, M.D.

Intratumoral AST-008 Combined With Pembrolizumab in Patients With Advanced Solid Tumors

NCT ID : 03684785
Protocol Number : AST-008-102
Phase : 1b/2
Location : Santa Monica, CA

All Solid Tumors

Steven O' Day, M.D.

Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage IIB or IIIA Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)

NCT ID : 03425643
Protocol Number : MK-3475-671
Phase : 3
Location : Santa Monica, CA

Melanoma, Skin and Soft Tissue Tumors

Minimally Invasive Chest Surgery and Thoracic Surgical Oncology

Steven O' Day, M.D.