What is a clinical trial?

Clinical trials are research studies designed to evaluate experimental treatments and procedures. Most breakthroughs in the diagnosis, treatment, and care of patients with cancer exist because of clinical trials.

Clinical trials have specific treatment plans with specific eligibility criteria. Criteria differ from study to study, and are frequently based on age, sex, type/stage of cancer, medical history, and current health status. Participation in a trial requires the ability to travel to the clinical trial center (in this case, the Saint John’s Cancer Institute).

See Clinical Trials FAQs for additional information.

Clinical trial research gave a cancer patient a second chance at life: a testimonial.

Mark Perzley is interviewed by Saint John’s Cancer Institute in Santa Monica, California.

Have questions?

For more information about any of our clinical trials, or general questions, please call our main hotline.   See Clinical Trials FAQs for additional information.

Please call, 310-582-7448 to participate in a clinical trial

The clinical trials listed below represent active and enrolling trials. We implement, initiate, and oversee clinical trials here, at Saint John’s Cancer Institute, as well as other facilities in the Southern California region.

Search using key terms or filter by Centers of Excellence or by Lead Doctor.

Title Center Name Physician

Study of Magrolimab in Participants With Solid Tumors

NCT ID : NCT04827576
Protocol Number : JWC_GS-US-548-5918
Phase : 2
Location : Santa Monica, Ca

Multiple Tumors

Przemyslaw Twardowski, M.D.

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

NCT ID : NCT03486873
Protocol Number : JWC_MK3475-587
Phase : 3
Location : Santa Monica, Ca

Melanoma, Skin and Soft Tissue Tumors

Przemyslaw Twardowski, M.D.

Women’s Alzheimer’s-Related Inflammation and Immunoregulatory Deficiency

NCT ID : N/A
Protocol Number : JWC_1653
Phase : N/A
Location : Santa Monica, Ca

Brain Tumors & Neuroscience

Verna Porter, M.D.

POA Retrospective Repository

NCT ID : NCT03326479
Protocol Number : JWC_COE-002-1116
Phase : N/A
Location : Santa Monica, Ca

Multiple Tumors

Naveed Wagle, M.D.

The Management of Acromegaly (MACRO) Registry

NCT ID : N/A
Protocol Number : JWC_OOO-ACM-RG1 MACRO
Phase : N/A
Location : Santa Monica, Ca

Brain Tumors & Neuroscience

Garni Barkhoudarian, M.D.

A Phase I Study of AGEN1181, an Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Subjects with Advanced Cancer

NCT ID : 03860272
Protocol Number : JWC_C-800-01
Phase : 1
Location : Santa Monica, CA

Multiple Tumors

Kim Margolin, M.D.

Study of Zirconium Zr 89 Crefmirlimab Berdoxam PET/CT in Subjects With Advanced or Metastatic Malignancies (iPREDICT)

NCT ID : 05013099
Protocol Number : JWC_IAB-CD8-203
Phase : 2b
Location : Santa Monica, CA

Multiple Tumors

Kim Margolin, M.D.

Outcomes of Cutaneous Melanoma Patients Clinically Tested with DecisionDx®-Melanoma: A Prospective Registry (CONNECTION PRO)

NCT ID : N/A
Protocol Number : JWC_CBI_2021_COCM_PRO
Phase : N/A
Location : Santa Monica, Ca

Melanoma, Skin and Soft Tissue Tumors

Richard Essner, M.D.

An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With SoC, Versus SoC Alone, in Adult Male Patients With mHSPC (PSMAddition)

NCT ID : 04720157
Protocol Number : JWC_CAAA617C12301 (Novartis)
Phase : III
Location : Santa Monica, Ca

Urology and Urologic Oncology

Przemyslaw Twardowski, M.D.

Recurrent GBM Treated With Neurosurgical Resection and IORT Using the Xoft Axxent eBx System and Bevacizumab (IORT)

NCT ID : 04681677
Protocol Number : JWC_CTPR-0017 GLIOX
Phase : 2
Location : Santa Monica, Ca

Brain Tumors & Neuroscience

Naveed Wagle, M.D.

IO102-IO103 in Combination With Pembrolizumab Versus Pembrolizumab Alone in Advanced Melanoma (IOB-013 / KN-D18)

NCT ID : 05155254
Protocol Number : IO102-IO103-013
Phase : III
Location : Santa Monica, Ca

Melanoma, Skin and Soft Tissue Tumors

Kim Margolin, M.D.

A Randomized Phase II, Open-label, Active-controlled, Multicenter Study Investigating the Efficacy and Safety of UV1 Vaccination in Combination with Nivolumab and Ipilimumab as First-line Treatment of Patients with Unresectable or Metastatic Melanoma (UV1-202)

NCT ID : 04382664
Protocol Number : JWC_UV1-202
Phase : II
Location : Santa Monica, Ca

Melanoma, Skin and Soft Tissue Tumors

Kim Margolin, M.D.

A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating The Efficacy And Safety Of Multiple Treatment Combinations In Patients With Melanoma (MORPHEUS-MELANOMA)

NCT ID : 05116202
Protocol Number : JWC_BO43328_Roche
Phase : I/II
Location : Santa Monica, Ca

Melanoma, Skin and Soft Tissue Tumors

Kim Margolin, M.D.

Prospective, Multi-Center, Randomized Study To Assess The Ability Of The Hydriphilix HDX Urinary Catheter To Reduce BIOFILM Formation When Compared To Two Types Of Commercially Available Foley Catheters (LATEX INFECTION CONTROL AND SILICONE-COATED LATEX)

NCT ID : 04841226
Protocol Number : JWC_STC-001
Phase : 3
Location : Santa Monica, CA

Urology and Urologic Oncology

Jennifer Linehan, M.D.

Saint John’s Cancer Institute Biospecimen Repository Protocol

Protocol Number : JWC_JWCI-REPOSITORY
Phase : N/A
Location : Santa Monica, CA

Multiple Tumors

Jennifer Linehan, M.D.

Oncoplastic partial mastectomy with Intraoperative Radiation Therapy (IORT) in early stage breast cancer patients with prior history of chest wall radiation

NCT ID : 05289466
Protocol Number : JWC_OBCSwIORTpriorRT
Phase : 3
Location : Santa Monica, CA

Breast Surgery and Oncology

Janie Grumley, M.D.

A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer (TAILOR RT).

NCT ID : 03488693
Protocol Number : JWC_CCTGMA.39
Phase : 3
Location : Santa Monica, CA

Breast Surgery and Oncology

Janie Grumley, M.D.

TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing Cancer

NCT ID : NCT04246671
Protocol Number : JWC_TAEK-VAC-HerBy-001
Phase : 1
Location : Saint John's Cancer Institute

All Solid Tumors

Santosh Kesari, M.D.

(TRIDENT) Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM (EF-32)

NCT ID : NCT04471844
Protocol Number : JWC_EF-32 Trident
Phase : N/A
Location : Saint John's Cancer Institute

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme (WHO Grade IV)

NCT ID : NCT04762069
Protocol Number : CNS-201
Phase : 2
Location : Saint John's Cancer Institute

Brain Tumors & Neuroscience

Naveed Wagle, M.D.

Study Evaluating Efficacy & Safety of Afuresertib Plus Fulvestrant in Patients w/ Locally Advanced or Metastatic HR+/HER2- Breast Cancer

NCT ID : NCT04851613
Protocol Number : LAE205INT3101
Phase : Phase Ib/II
Location : Saint John's Cancer Institute

Breast Surgery and Oncology

Clinical Trials

Parvin Peddi, M.D.

Study to Evaluate the Safety and Efficacy of Magrolimab in Combination With Nab-Paclitaxel or Paclitaxel Versus Nab-Paclitaxel or Paclitaxel in Previously Untreated Adults With Metastatic Triple-Negative Breast Cancer

NCT ID : NCT04958785
Protocol Number : JWC_GS-US-586-6144
Phase : 2
Location : Saint John's Cancer Institute

Breast Surgery and Oncology

Parvin Peddi, M.D.

T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial

NCT ID : NCT04457596
Protocol Number : A011801
Phase : Phase III
Location : Saint John's Cancer Institute

Breast Surgery and Oncology

Clinical Trials

Parvin Peddi, M.D.

Testing Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases

NCT ID : 04647916
Protocol Number : SWOG S2007
Phase : 2
Location : Saint John's Cancer Institute

Breast Surgery and Oncology

Clinical Trials

Parvin Peddi, M.D.

A Phase 1/2 Study of PBI-200 in Subjects with NTRK-Fusion-Positive Advanced or Metastatic Solid Tumors

NCT ID : NCT04901806
Protocol Number : JWC_PBI-200-101
Phase : 1/2
Location : Santa Monica, CA

Multiple Tumors

Naveed Wagle, M.D.

Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subject with mCRPC (CONTACT-02)

NCT ID : 04446117
Protocol Number : JWC_XL184-315
Phase : 3
Location : Santa Monica, CA

Urology and Urologic Oncology

Przemyslaw Twardowski, M.D.

White Button Mushroom Sup for the Reduction of PSA in Pts With Biochemically Rec or Therapy Naive Fav Risk Prostate CA

NCT ID : 04519879
Protocol Number : JWC_White Button Mushroom
Phase : 2
Location : Santa Monica, CA

Urology and Urologic Oncology

Przemyslaw Twardowski, M.D.

Evaluation of the PhageTech Virus BioResistor

NCT ID : 04756284
Protocol Number : VBRm BCA-01
Phase : Pilot/Feasibility
Location : Santa Monica, CA

Urology and Urologic Oncology

Jennifer Linehan, M.D.

Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies

NCT ID : 04566393
Protocol Number : JWC_ULI-EAP-100
Phase : N/A
Location : Santa Monica, CA

Multiple Tumors

Naveed Wagle, M.D.

Caris Biorepository Research Protocol

NCT ID : 01499394
Protocol Number : JWC_TCBIO-001-0710
Phase : N/A
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Naveed Wagle, M.D.

Synuclein-One Study

NCT ID : 04700722
Protocol Number : JWC_Synuclein
Phase : N/A
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Melita Petrossian, M.D.

Allogeneic Human Mesenchymal Stem Cells for Alzheimer’s Disease

NCT ID : 02833792
Protocol Number : STEM105-M-AD
Phase : 2
Location : Santa Monica, CA

Stroke and Neurovascular Research

Santosh Kesari, M.D.

Extension Study for Patients Who Had Not Met Criteria for Discontinuation in Previous Sponsored Belinostat Trials

NCT ID : 04184869
Protocol Number : JWC_SPI-BEL-502
Phase : N/A
Location : Santa Monica, CA

Multiple Tumors

Santosh Kesari, M.D.

An Open-label, Nonrandomized, Phase 1 Drug-Drug Interaction Study to Evaluate the Pharmacokinetics of Belinostat in Combination with Atazanavir in Patients with Advanced Relapsed/Refractory Solid Tumors or Hematological Malignancies

NCT ID : 099999999
Protocol Number : JWCI_SPI-BEL-107
Phase : 1
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

The PREVENTION Trial: Precision Recommendations to Optimize Neurocognition (PREVENTION)

NCT ID : 04082611
Protocol Number : Prevention
Phase : N/A
Location : Santa Monica, CA

Brain Tumors & Neuroscience

David Merrill, M.D.

Intermediate-size Expanded Access to ONC201 for Patients with H3 K27M-mutant and/or Midline Gliomas

NCT ID : 04617002
Protocol Number : JWC_ONC028 Oncoceutics
Phase : N/A
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Akanksha Sharma, M.D.

Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body (ON-TRK)

NCT ID : 04142437
Protocol Number : JWC_ON-TRK
Phase : N/A
Location : Santa Monica, CA

Multiple Tumors

Naveed Wagle, M.D.

Open-label Study Investigating of OKN-007 Combined With Temozolomide in Patients With Recurrent Glioblastoma

NCT ID : 04388475
Protocol Number : JWC_OKN-007
Phase : 2
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

mSIM: Mobile Simultaneous Aerobic Exercise and Memory Training Intervention for Older Adults With Amnestic Mild Cognitive Impairment (mSIM)

NCT ID : 04185298
Protocol Number : JWC_MSIM
Phase : N/A
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Jennifer Bramen, M.D.

A Study of MPT-0118 in Subjects With Advanced or Metastatic Refractory Solid Tumors

NCT ID : 04859777
Protocol Number : JWC_MPT-0118-101
Phase : 1/b
Location : Santa Monica, CA

All Solid Tumors

Multiple Tumors

Przemyslaw Twardowski, M.D.

The PREDICT Registry for DCIS Patients With DCISionRT Testing (PREDICT)

NCT ID : 03448926
Protocol Number : DCISionRT Registry
Phase : N/A
Location : Santa Monica, CA

Breast Surgery and Oncology

Janie Grumley, M.D.

Evaluating the Clinical Efficacy of an Early-Stage Lung Cancer Detector

NCT ID : N/A
Protocol Number : CPC001-2017-S5P4-PSJHC
Phase : N/A
Location : Santa Monica, CA

Minimally Invasive Chest Surgery and Thoracic Surgical Oncology

Robert McKenna, M.D.

POA Prospective Repository

NCT ID : 03324841
Protocol Number : JWC_Caris-COE-002-0815
Phase : N/A
Location : Santa Monica, CA

Multiple Tumors

Naveed Wagle, M.D.

DecisionDx-Melanoma Impact on Sentinel Lymph Node Biopsy Decisions and Clinical Outcomes (DECIDE)

NCT ID : N/A
Protocol Number : CBI_2019_SLNBprosp_001
Phase : N/A
Location : Santa Monica, CA

Melanoma, Skin and Soft Tissue Tumors

Richard Essner, M.D.

Trial With BNT111 and Cemiplimab in Combination or as Single Agents in Patients With Anti-PD1-refractory/Relapsed, Unresectable Stage III or IV Melanoma

NCT ID : 04526899
Protocol Number : JWC_BNT111-01
Phase : 2
Location : Santa Monica, CA

Melanoma, Skin and Soft Tissue Tumors

Kim Margolin, M.D.

Liquid Biopsy Evaluation Of Biomarkers In Various Clinical Specimen Types From Patient With Cancer

NCT ID : N/A
Protocol Number : JWC_BIOC-035
Phase : Pilot/Feasibility
Location : Santa Monica, CA

Multiple Tumors

Naveed Wagle, M.D.

A First in Human Study of AdAPT-001 in Subjects With Refractory Solid Tumors (BETA-PRIME)

NCT ID : 04673942
Protocol Number : JWC_BETA PRIME
Phase : 1
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

Optimizing Endocrine Therapy Through Motivational Interviewing and Text Interventions

NCT ID : 04379570
Protocol Number : A191901
Phase : 4
Location : Santa Monica, CA

Breast Surgery and Oncology

Janie Grumley, M.D.

Embolization of the Middle Meningeal Artery With ONYX™ Liquid Embolic System In the Treatment of Subacute and Chronic Subdural Hematoma (EMBOLISE)

NCT ID : 04402632
Protocol Number : MDT19027ONYX
Phase : N/A
Location : Providence Little Company of Mary Medical Center: 4101 Torrance Blvd, Torrance, CA

Clinical Trials

Stroke and Neurovascular Research

Translational Neurosciences

Jason Tarpley, M.D. & Walavan Sivakumar, M.D.

The TESLA Trial: Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke

NCT ID : 03805308
Protocol Number : JWC_TESLA_G190006
Phase : 3
Location : Providence Little Company of Mary Medical Center: 4101 Torrance Blvd, Torrance, CA

Clinical Trials

Stroke and Neurovascular Research

Jason Tarpley, M.D.

A Study of Belzutifan (MK-6482) in Combination With Lenvatinib (MK-7902) Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)

NCT ID : 04586231
Protocol Number : JWC_MK6482-011
Phase : 3
Location : Santa Monica

Urology and Urologic Oncology

Przemyslaw Twardowski, M.D.

Enfortumab Vedotin and Pembrolizumab, With or Without Chemotherapy, vs. Chemotherapy Alone in Untreated Locally Advanced or Metastatic Urothelial Cancer (EV-302)

NCT ID : 04223856
Protocol Number : SGN22E-003
Phase : 3
Location : Santa Monica, CA

Urology and Urologic Oncology

Przemyslaw Twardowski, M.D.

A Retrospective Study Observational Study for H3 K27M-nutenat and/or Midline Gliomas

NCT ID : N/A
Protocol Number : ONC019
Phase : N/A
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Akanksha Sharma, M.D.

A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome (GRACE)

NCT ID : 03697109
Protocol Number : CORT125134-455
Phase : 3
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Garni Barkhoudarian, M.D.

Pemetrexed for the Treatment of Chordoma

NCT ID : 03955042
Protocol Number : JWCI-18-0704
Phase : 1
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

Perioperative Pembrolizumab (MK-3475) Plus Neoadjuvant Chemotherapy Versus Perioperative Placebo Plus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle-invasive Bladder Cancer (MIBC) (MK-3475-866/KEYNOTE-866)

NCT ID : 03924856
Protocol Number : MK-3475-866/KEYNOTE-866
Phase : 3
Location : Santa Monica, CA

Urology and Urologic Oncology

Przemyslaw Twardowski, M.D.

Memantine XR and Pregabalin for Chemotherapy-Induced Peripheral Neuropathy

NCT ID : 03709888
Protocol Number : JWCI-17-0101
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Santosh Kesari, M.D.

Optune Delivered Electric Field Therapy and Bevacizumab in Treating Patients With Recurrent or Progressive Grade 2 or 3 Meningioma

NCT ID : 02847559
Protocol Number : NU 16C02
Phase : 2
Location : Santa Monica, CA

Brain Tumors & Neuroscience

Santosh Kesari, M.D.