Translating Advanced Cancer Research into Personalized, Passionate Treatment.
Saint John’s Cancer Institute (formerly John Wayne Cancer Institute) is a cancer research institute dedicated to the understanding, diagnosis, and innovative treatment of cancer in order to eliminate patient suffering and prolong survival.Read More
Cancer Innovation Newsletter
The world class cancer clinicians and translational scientists at the Saint John’s Cancer Institute in Santa Monica, CA, work collaboratively to advance patient care. Our patients have access to the latest treatments and cutting edge new drug clinical trials. We are at the forefront of transforming discoveries leading to advancements in cancer medicine and patient survival.
We invite you to download a copy of Cancer Innovation, the quarterly newsletter of the Saint John’s Cancer Institute, created to bring you the latest news and compelling stories from our cancer departments, highlighting our innovative work, nurturing care and groundbreaking research.Read the Fall 2020 Issue
Clinical trials have always been an important part of Saint John’s Cancer Institute. Our institute led the trials that established sentinel lymph node biopsy as the standard of care for melanoma and breast care and pioneered immunotherapy as treatment for melanoma. Today, our patients continue to have access to the latest treatments and trials. We are at the forefront of studying the biology of cancer as well as expanding treatment for those suffering world-wide.Learn More
Attracting Patients from Around the World
As international leaders in cancer care, the Saint John’s Cancer Institute attracts patients from all over the country and around the world. Seeing such a large number of patients, our team of experts bring a high level of experience to every aspect of your treatment. We’re with you from diagnosis through cure and have a team approach for better outcomes.Meet our Experts
Complex Surgical Oncology Fellowship
With a longstanding history of excellence in multidisciplinary cancer care and education, the Saint John’s Cancer Institute continues to be a leader in training the next generation of leaders in the field of surgical oncology.Learn more about this fellowship
Urologic Oncology Fellowship
Providing world class, multidisciplinary training in genitourinary malignancies and urologic oncology research with innovative and cutting edge technology.Learn more about this fellowship
This training program focuses on endonasal endoscopic and keyhole surgical approaches, neuro-endoscopy, pituitary tumor management and multimodality neuro-oncology treatments.Learn more about this fellowship
Postdoctoral Lab-Based Translational Molecular Medicine Fellowship
As pioneers in translational studies on “liquid biopsies” involving circulating tumor cells in multiple types of solid tumors, the fellowship program also consists of studying epigenetic mechanisms regulating solid tumor as well as pharmacogenomics and immunogenomic based prediction of response to therapy.Learn more about this fellowship
Latest News & Events
Olaparib for Metastatic Castration-Resistant Prostate Cancer
Przemyslaw W. Twardowski, M.D., and his colleagues, have published a new study in the New England Journal of Medicine, which demonstrates significant benefit of therapy with olaparib (PARP inhibitor) in patients with advanced prostate cancer who harbor certain mutations of DNA repair system and who failed standard treatments. Based on the results of that study on 5/19/2020 Food and Drug Administration (FDA) granted approval of olaparib, providing a valuable treatment option for about 25% of patients with advanced prostate cancer with certain mutations of DNA repair. These mutations can be detected by performing an analysis of a patient’s cancer specimen and sometimes also on a specialized blood test.
ANG1005, a Brain Penetrating Peptide-Drug Conjugate, Shows Activity in Patients With Breast Cancer With Leptomeningeal Carcinomatosis and Recurrent Brain Metastases
The department of Translational Neurosciences studied ANG1005, a novel taxane derivative, which consists of 3 paclitaxel molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via LRP1 transport system. Read the publication to learn the results.
Prognostic Impact and Utility of Immunoprofiling in the Selection of Patients with Colorectal Peritoneal Carcinomatosis for Cytoreductive Surgery (CRS) and Heated Intraperitoneal Chemotherapy (HIPEC)
This is the first study to assess the utility of subtypes of T cells as prognostic markers in patients with colorectal peritoneal carcinomatosis, which may play a role in patients with low-volume disease. The purpose of this study is to evaluate immune profiles of patients with peritoneal carcinomatosis and their correlation with overall survival (OS).