Study to Evaluate the Safety and Efficacy of Magrolimab in Combination With Nab-Paclitaxel or Paclitaxel Versus Nab-Paclitaxel or Paclitaxel in Previously Untreated Adults With Metastatic Triple-Negative Breast Cancer

Phase II study of Margolimab in combination with nab-paclitaxel in the first line setting in patients with metastatic triple negative breast cancer who are negative for PD-L1 expression. Novel immunotherapy approach targeting macrophage check point.

The primary objective of this study for the Safety Run-In Cohort is to evaluate the safety, tolerability, and recommended Phase 2 dose (RP2D) of magrolimab in combination with nab-paclitaxel or paclitaxel in metastatic triple-negative breast cancer (mTNBC).

The primary objective of this study for the Randomized Cohorts is to evaluate the efficacy of magrolimab in combination with nab-paclitaxel or paclitaxel in solid tumors as determined by progression-free survival (PFS) by investigator assessment.

Learn More at clinicaltrials.gov

To participate please call: 310-582-7448