How do modifications to RNA molecules influence tumor biology?

We are currently using third-generation sequencing technologies to explore the diversity of RNA modifications in tumors.

  • Breast cancer epi-transcriptome
    • Some of the questions we are working on:
      • How do RNA modifications differ among tumor subtypes?
      • What role do RNA modifications play in the development of treatment resistance?
      • What role do RNA modifications play in metastasis?
      • Can we identify therapeutic targets within the epi-transcriptome?