Goals and Objectives
The overall goal of the TETR Program is to discover and validate novel therapeutic targets, and develop safe, effective, and patentable experimental drugs and treatment strategies for cancer. A primary objective of the TETR Program is identification of clinically relevant new cancer therapies paired with laboratory research to facilitate translational research. Our research has a strong clinical and translational orientation, aligned along four main fast and cost-effective research themes depending on the demands of the project.
- Drug Discovery: Multidisciplinary chemical (New drug/Repurposed) approaches towards discovery of novel patentable experimental therapeutics in Oncology and CNS disease targets and biomarkers.
- Drug Delivery: Develop novel lipid-based nanoparticle and small molecule drug conjugated prodrug delivery platforms to enhance cancer therapy.
- Combination Therapy: Combine immunotherapy and standard-of-care therapy (chemotherapy and radiation), with our lead experimental drugs to increase overall treatment efficiency and improve patient outcomes.
- Clinical Research: Fostering translation of discoveries between the laboratory and clinic through collaborations and scientific synergy among SJCI members.
TETR Program Services
The Translational Experimental Therapeutic (TET) research program offers a variety of drug discovery /development and delivery services for SJCI internal and external principal investigators, depending on their project needs. Our program allies with top level academic institutions and custom research organization companies to bring our ideas to fruition. Listed below are some of the major activities of TETR program.
- In Silico Drug Discovery: Our program supports a variety of computational-aided drug design (CADD) methods to identify new chemical entities for druggable and undruggable disease targets of your interest.
- Medicinal Chemistry And Structure-Activity Relationship (Sar): Our program supports the building of a diversified and focused chemical scaffold library for your hits, to perform SAR studies and identify patentable lead analogs.
- Drug Target Engagement Studies: Our program supports the design of a variety of cell free and cell-based target engagement studies to validate experimental drugs for biomarker mediated mechanistic studies. We further apply -omics methods to understand signaling pathways and identify the most vulnerable patient population for lead experimental drugs.
- Resistance Mechanism and Combination Studies: Our program investigates the resistance mechanisms of lead experimental drugs and addresses this by developing drug combinations.
- Drug Metabolism, Pharmacokinetics and Pharmacodynamics: Our program can coordinate preclinical studies to establish experimental drug pharmacology and toxicity profiles, to allow for dose adjustment and optimization of the route of administration.
- Drug Formulations: Our program supports developing lipid-based nanoparticle formulations and small molecule drug conjugate pro-drug formulations to improve the therapeutic index of experimental drugs as well as clinically active drugs.
- Grant Support: In addition to the above services, our program will help you build specific aims for your project and identify suitable grant agencies for the best chance at success in securing funding.
Our multidisciplinary services are proven to translate your biology insights to meaningful patentable therapeutics.