Cancer Therapeutic Studies
More than 18,000 Americans develop a tumor in the brain or central nervous system annually, and the number of patients with metastatic brain tumors continues to grow. Although progress has been made, many brain tumors do not respond to standard treatments like chemotherapy and radiotherapy and surgery remains the only approved option for patient with brain cancer. Therefore, there is an urgent need for better treatments and management strategies for brain cancer. In the Translational Neurosciences and Neurotherapeutics Laboratory, we take a comprehensive, interdisciplinary approach to gain a better molecular and biological understanding of malignant gliomas and other brain tumors. We integrate studies on tumor genetics, tumor microenvironment, and chemoresistance in brain tumors, as well as other type of cancers (i.e., colon, ovarian, breast, and prostate), and translate them into practical application and novel therapies for patients.