Cancer research at Saint John’s Cancer Institute continues to promote deeper understanding across the field of oncology.
Through laboratory discovery, clinical investigation, and multidisciplinary collaboration, our researchers work to translate scientific insight into meaningful improvements in patient care. Each study represents a step toward safer treatments, earlier detection, and more personalized approaches to cancer therapy.
In 2025, Saint John’s Cancer Institute researchers published 74 peer-reviewed studies across more than a dozen specialties and subspecialties, developed by 34 scientists and clinicians working alongside their research teams. These studies reflect collaboration both within the Institute and with research partners around the world, addressing complex questions in cancer biology, treatment innovation, and clinical outcomes.
Most Significant Publications Summarized
This year’s Research Report introduces a new Executive Summary, highlighting eight highly significant publications that demonstrate the breadth and impact of our scientific work. These selected studies highlight three categories of our foremost articles across different disciplines: Clinical Trials, Translational Research, and Clinical Research, spanning Molecular Biology, Precision Diagnostics, and Clinical Trials, including Immunotherapy, Surgery, and Acute Neurologic Care. Together, these publications, among dozens of others, reflect SJCI’s strength in translating foundational science into clinically meaningful advances, while simultaneously shaping standards of care through high-impact clinical investigation.
New Translational and Precision Medicine Lab
Saint John’s Cancer Institute also continues to expand its research infrastructure. In 2025, the Institute launched the Translational and Precision Medicine (TPM) Laboratory, led by Matias Bustos, Ph.D. The TPM Lab advances precision-focused approaches to cancer research, supporting efforts to better understand tumor biology and accelerate the translation of laboratory discoveries into clinical applications. Under the leadership of Dave S.B. Hoon, Ph.D., SJCI’s molecular research programs continue to expand, with ongoing discoveries in metastatic melanoma biology and mRNA-driven cancer research.
Fellowship-driven Science
Many of our research initiatives are guided by faculty-fellow mentoring programs, in which fellows participate in research across multiple disciplines, including translational science, urology, breast oncology, neuroscience, endocrine disorders, complex general surgery, and melanoma. Working closely with experienced faculty mentors, fellows contribute to a collaborative environment that helps cultivate the next generation of physician-scientists.
The progress reflected in the 2025 Research Report represents the collective dedication of our researchers, clinicians, fellows-in-training, and administrators. Through their work, Saint John’s Cancer Institute continues to advance scientific knowledge while remaining focused on the ultimate goal—improving the lives of patients facing cancer.
SJCI Research Reports
- 2025 Research Report (PDF)
- 2024 Research Report (PDF)
- 2023 Research Report (PDF)
- 2022 Research Report (PDF)
Cutting-edge research is possible through grants and your donations.
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