Together We're Finding a Cure!

In 2019, it is expected that 268,600 new cases of breast cancer will be diagnoses in women.

Breast cancer research continues to be an integral part of the John Wayne Cancer Institute. Cancer research allows us to understand breast cancer, find minimally invasive treatment options, and ultimately find a cure. Many of the physicians and surgeons who are treating and caring for patients in the Margie Petersen Breast Center at Providence Saint John’s are also faculty, adjunct faculty, or physicians in a fellowship program affiliated with the John Wayne Cancer Institute.

Our physicians work directly with our research scientists to advance patient care. By studying the mechanism of breast cancer, our researchers can translate lab-based discoveries into personalized bedside treatment. This approach fosters a truly beneficial experience for our patients, as they lead to novel findings and new directions for therapeutic interventions.

Learn About Our Translational Research Departments
Breast Cancer Research

Breast Research Studies

John Wayne Cancer Institute Biospecimen & Research Data Repository

(PI: Dr. Jennifer Linehan)

This study involves collection of biological specimens (blood, tissue, urine, etc.) from patients with potential or known cancer, who are seen at Providence Saint John’s Health Center. Biological samples are collected when procedures are performed as part of the patient’s routine medical evaluations. By collecting these specimens, we plan to create and maintain a repository to make data and specimens available for researchers to discover predictive biomarkers, patterns of care and outcomes, and personalized treatments that could directly improve the care of our patients. This consent is used to collect tissue and blood samples for the translational studies currently being performed at John Wayne Cancer Institute.

Multidisciplinary Research Registry for Malignant and Benign Breast Disease

(PI: Dr. Janie Grumley)

The objective of this project is to develop and manage a Breast Program Research Registry for the purpose of:

  • Performing retrospective, observational research and quality improvement studies in patients with breast disease.
  • Critically assessing diagnostic and treatment procedures provided at Providence Saint John’s Health Center (PSJHC) for both benign and malignant breast disease.
  • Assessing short and long term outcomes based on disease sub-types and diagnostic and treatment modalities in patients with breast disease.

Research Registry for Intra-Operative Radiotherapy (IORT) after breast conserving therapy in the treatment of in situ and early stage breast cancer

(PI: Dr. Janie Grumley)

The objective of this project is to develop and prospectively evaluate patient outcome in patients with early stage breast cancer treated with IORT. The purpose of the registry includes:

  • Performing retrospective, observational research in patients with early stage and in situ breast cancer who were treated with IORT as part of breast conserving therapy at Providence Saint John’s Health Center.
  • Assessing short and long term local and distant disease recurrence in patients who received IORT.
  • Assessing disease free survival and overall survival of patients treated with IORT.
  • Retrospectively assessing perioperative and long term complications associated with IORT.

Clinical Trials

Clinical trials are scientific studies that find a better way to prevent, screen, diagnose, and treat diseases. Most advances in the diagnosis, treatment, and care of patients with cancer have occurred because of clinical trials.

Our clinical trials are designed to evaluate:

  • Modifications to existing or “standard” treatment for specific cancers
  • New experimental drugs or agents
  • New experimental ways to care for people with cancer as they receive treatment
  • Experimental methods of identifying cancer